RT Journal Article
T1 Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples.
A1 Messerlian, Carmen
A1 Braun, Joseph M
A1 Mínguez-Alarcon, Lidia
A1 Williams, Paige L
A1 Ford, Jennifer B
A1 Mustieles, Vicente
A1 Calafat, Antonia M
A1 Souter, Irene
A1 Toth, Thomas
A1 Hauser, Russ
K1 Birth weight
K1 Maternal exposure
K1 Paternal exposure
K1 Phthalates
K1 Preconception
AB Prenatal phthalate exposure has been inconsistently associated with fetal growth and infant birth weight. However, the effect of exposure during the paternal and maternal preconception period remains understudied. To investigate associations of paternal and maternal preconception and maternal prenatal urinary phthalate metabolite concentrations with birth weight. The study comprised 364 singletons born to 364 mothers and 195 fathers (195 couples) from the EARTH Study, a prospective cohort of couples from Boston, MA. Births were categorized by mode of conception: in-vitro fertilization based (IVF) (n=208) or non-IVF based (n=156, intrauterine insemination or non-medically assisted/natural conception). We measured urinary concentrations of eleven phthalate metabolites in maternal (n=1425) and paternal (n=489) preconception and maternal prenatal (n=781) samples. Birth weight was abstracted from delivery records. Covariate-adjusted associations between loge-phthalate metabolite concentrations and birth weight were evaluated separately by mode of conception using multivariable linear regression. Each loge-unit increase in paternal urinary concentration of the sum of di(2-ethylhexyl) phthalate (ΣDEHP) metabolites was associated with a 90 gram (95% CI: -165, -15) decrease in birth weight among IVF singletons, but not among non-IVF singletons (18g; 95% CI: -76, 113). Additional adjustment for maternal prenatal ΣDEHP concentrations modestly strengthened findings among IVF singletons. While few associations were found with maternal preconception phthalate metabolites, we observed an inverse relationship between several maternal prenatal urinary phthalate metabolite concentrations and birth weight among IVF singletons in covariate-adjusted models. However, with further adjustment for specific paternal phthalate metabolite concentrations, these associations were attenuated and no longer significant. Paternal preconception urinary concentration of ΣDEHP metabolites was associated with a decrease in birth weight among IVF-conceived singletons. These results, if replicated, highlight the importance of preconception health, especially among subfertile couples.
PB Elsevier Ltd
YR 2017
FD 2017-06-16
LK http://hdl.handle.net/10668/11362
UL http://hdl.handle.net/10668/11362
LA en
NO Messerlian C, Braun JM, Mínguez-Alarcón L, Williams PL, Ford JB, Mustieles V, et al. Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples. Environ Int. 2017 Oct;107:55-64.
NO Work supported by grants ES R01 009718 from the National Institute of Environmental Health Sciences (NIEHS). CM was supported by a post-doctoral fellowship award from the Canadian Institutes of Health Research.
DS RISalud
RD Apr 9, 2025