TY  - JOUR
AU  - Fudio, Salvador
AU  - Tabernero, Josep
AU  - Subbiah, Vivek
AU  - Chawla, Sant P
AU  - Moreno, Victor
AU  - Longo, Federico
AU  - Lopez, Rafael
AU  - Anton, Antonio
AU  - Trigo, Jose Manuel
AU  - Shapiro, Geoffrey
AU  - Jeong, Woondong
AU  - Villalobos, Victor Manuel
AU  - Lubomirov, Rubin
AU  - Fernandez-Teruel, Carlos
AU  - Alfaro, Vicente
AU  - Boni, Valentina
PY  - 2020
DO  - 10.1007/s00280-020-04153-6
UR  - http://hdl.handle.net/10668/16488
T2  - Cancer chemotherapy and pharmacology
AB  - This study assessed the effect of lurbinectedin, a highly selective inhibitor of oncogenic transcription, on the change from baseline in Fridericia's corrected QT interval (∆QTcF) and electrocardiography (ECG) morphological patterns, and lurbinectedin...
LA  - en
PB  - Springer Nature
KW  - Cardiac repolarization
KW  - ECG
KW  - Effect compartment
KW  - Lurbinectedin
KW  - Plasma concentration
KW  - QTcF
KW  - Adult
KW  - Aged
KW  - Antineoplastic agents
KW  - Carbolines
KW  - Electrocardiography
KW  - Female
KW  - Heterocyclic compounds, 4 or more rings
KW  - Humans
KW  - Male
KW  - Middle aged
KW  - Neoplasms
KW  - Prospective studies
TI  - Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis.
TY  - research article
VL  - 87
ER  -