RT Journal Article
T1 A Knockout IFNL4 Variant Is Associated With Protection From Sexually Transmitted HIV-1 Infection.
A1 Jaimes-Bernal, Claudia
A1 Rallon, Norma
A1 Benito, Jose M
A1 Omar, Mohamed
A1 Gomez-Vidal, Maria Amparo
A1 Marquez, Francisco Jose
A1 Sanchez-Arcas, Beatriz
A1 Trujillo, Monte
A1 Royo, Jose Luis
A1 Saulle, Irma
A1 Biasin, Mara
A1 Rivero-Juarez, Antonio
A1 Caruz, Antonio
K1 HIV-1
K1 IFNA
K1 IFNL4
K1 USP18
K1 High exposed seronegatives
AB An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection. The role of this polymorphism in the susceptibility to human immunodeficiency virus type 1 (HIV-1) infection is controversial. This study aimed to assess the association of this knockout IFNL4 variant and sexually transmitted HIV-1 infection. A total of 228 HIV-1-positive individuals and 136 HIV-exposed seronegative individuals were investigated for their association with IFNL4 rs368234815 genotypes. The IFNL4 ΔG functional allele is associated with increased susceptibility to HIV-1 infection through the sexual route (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.6; P = .004). A meta-analysis including a population of injection drug users suggests a codominant mode of inheritance of this risk factor (OR, 2.0; 95% CI, 1.3-3.2; P = .001).
YR 2018
FD 2018-10-04
LK http://hdl.handle.net/10668/13033
UL http://hdl.handle.net/10668/13033
LA en
DS RISalud
RD Apr 7, 2025