RT Journal Article
T1 Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies.
A1 Aguilar-Castillo, Maria Jose
A1 Cabezudo-Garcia, Pablo
A1 Ciano-Petersen, Nicolas Lundahl
A1 Garcia-Martin, Guillermina
A1 Marin-Gracia, Marta
A1 Estivill-Torrus, Guillermo
A1 Serrano-Castro, Pedro Jesus
K1 epilepsy
K1 epileptogenesis
K1 neuroimmunology
K1 neuroinflammation
K1 treatment
AB Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources, it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. For this reason, we performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways involved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drugs.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-03-19
LK http://hdl.handle.net/10668/20824
UL http://hdl.handle.net/10668/20824
LA en
NO Aguilar-Castillo MJ, Cabezudo-García P, Ciano-Petersen NL, García-Martin G, Marín-Gracia M, Estivill-Torrús G, et al. Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies. Biomedicines. 2022 Mar 19;10(3):716
DS RISalud
RD Apr 5, 2025