RT Journal Article
T1 Neuroprotective Effect of 3',4'-Dihydroxyphenylglycol in Type-1-like Diabetic Rats-Influence of the Hydroxytyrosol/3',4'-dihydroxyphenylglycol Ratio.
A1 Rodriguez-Perez, Maria Dolores
A1 Perez de Algaba, Inmaculada
A1 Martin-Aurioles, Esther
A1 Arrebola, Maria Monsalud
A1 Ortega-Hombrados, Laura
A1 Verdugo, Cristina
A1 Fernandez-Prior, Maria Africa
A1 Bermudez-Oria, Alejandra
A1 De La Cruz, Jose Pedro
A1 Gonzalez-Correa, Jose Antonio
K1 3′,4′-dihydroxyphenylglycol
K1 diabetes mellitus
K1 diabetic neuropathy
K1 extra virgin olive oil
K1 hydroxytyrosol
K1 Área de Gestión Sanitaria Sur de Córdoba
K1 Área de Gestión Sanitaria Este de Málaga-Axarquía
AB The aim of this study was to assess the possible neuroprotective effect of 3',4'-dihydroxyphenylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect is modified by the presence of another EVOO polyphenol, hydroxytyrosol (HT). The neuroprotective effect was assessed in a hypoxia-reoxygenation model in brain slices and by quantifying retinal nerve cells. The animals were distributed as follows: (1) normoglycemic rats (NDR), (2) diabetic rats (DR), (3) DR treated with HT (5 mg/kg/day p.o.), (4) DR treated with DHPG (0.5 mg/kg/day), or (5) with 1 mg/kg/day, (6) DR treated with HT plus DHPG 0.5 mg/kg/day, or (7) HT plus 1 mg/kg/day p.o. DHPG. Diabetic animals presented higher levels of oxidative stress variables and lower numbers of neuronal cells in retinal tissue. The administration of DHPG or HT reduced most of the oxidative stress variables and brain lactate dehydrogenase efflux (LDH) as an indirect index of cellular death and also reduced the loss of retinal cells. The association of DHPG+HT in the same proportions, as found in EVOO, improved the neuroprotective and antioxidant effects of both polyphenols.
PB MDPI
YR 2022
FD 2022-03-07
LK http://hdl.handle.net/10668/21459
UL http://hdl.handle.net/10668/21459
LA en
NO Rodríguez-Pérez MD, Pérez de Algaba I, Martín-Aurioles E, Arrebola MM, Ortega-Hombrados L, Verdugo C, et al. Neuroprotective Effect of 3',4'-Dihydroxyphenylglycol in Type-1-like Diabetic Rats-Influence of the Hydroxytyrosol/3',4'-dihydroxyphenylglycol Ratio. Nutrients. 2022 Mar 8;14(6):1146
DS RISalud
RD Apr 11, 2025