%0 Journal Article
%A Cuadros, Marta
%A Andrades, Alvaro
%A Coira, Isabel F
%A Baliñas, Carlos
%A Rodriguez, Maria I
%A Alvarez-Perez, Juan Carlos
%A Peinado, Paola
%A Arenas, Alberto M
%A Garcia, Daniel J
%A Jimenez, Pilar
%A Camos, Mireia
%A Jimenez-Velasco, Antonio
%A Medina, Pedro P
%T Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.
%D 2019
%U http://hdl.handle.net/10668/14742
%X Acute lymphoblastic leukemia (ALL) is a clinically and biologically heterogeneous disease recurrently affected by chromosomal aberrations, including translocations, amplifications, and aneuploidies1. These aberrations have important implications for the diagnosis, sub-classification, prognosis and, overall, for making appropriate therapeutic decisions. The reciprocal translocation t(12;21)(p13;q22)[ETV6/RUNX1] is the most frequent chromosomal rearrangement in pediatric B-cell acute lymphoblastic leukemia (B-ALL) with an incidence of ~25%2. This rearrangement, as well as high hyperdiploidy, is associated with a favorable outcome under current treatment protocols, but up to 20% of ETV6-RUNX1positive pediatric B-ALL patients experience a late disease relapse1,3.
%K Biomarkers, Tumor
%K Core Binding Factor Alpha 2 Subunit
%K Gene Expression Profiling
%K Gene Expression Regulation, Neoplastic
%~