RT Journal Article T1 Editorial: Mathematical and computational methods in physiology. A1 Femia, Pedro A1 Melchor, Juan A1 Carmona-Saez, Pedro K1 biostatistical methods K1 computational methods K1 machine learning K1 mathematical physiology K1 modelling K1 omics integration AB Physiology constitutes a broad discipline that covers the study of the differenthierarchical levels of living organisms, from the cellular one to higher levels, such astissues or organs. The articles of this monography provide an excellent example of thetelescopic capacity of this discipline. A common nexus among all these levels is thatphysiological systems are epistemologically complex. This implies that their studyrequires a necessary reduction of the complexity in order to elaborate a formal andmanageable description of the system, giving rise to a model. Therefore, we need todevelop mathematical models that represent the original system instead of studying it.Nevertheless, even this representation can present an unmanageable degree of complexity.Typically, the description of the physiological processes relies on non-linear relationshipsamong a high number of variables that involve many parameters of unknown value. PB Frontiers Research Foundation SN 1664-042X YR 2022 FD 2022-07-07 LK http://hdl.handle.net/10668/20717 UL http://hdl.handle.net/10668/20717 LA en NO Femia P, Melchor J, Carmona-Saez P. Editorial: Mathematical and computational methods in physiology. Front Physiol. 2022 Aug 8;13:975075. NO PS acknowledges funding from Ministerio de Ciencia eInnovación (grant PID 2020-119032RB-I00) and FEDER/Junta deAndalucía-Consejería de Transformación Econímica, Industria,Conocimiento y Universidades (grants P20-00335 and B-CTS-40-UGR20), JM acknowledges funding from Ministerio de Ciencia eInnovación (grant PID 2019-106947RA-C22) and PRE 2018-086085(Co-funded by European Social Fund “Investing in your future”);Consejería de economía, conocimiento, empresas y universidad andEuropean Regional Development Fund (ERDF) SOMM17/6109/UGR and P18-RT-1653. DS RISalud RD Apr 11, 2025