RT Journal Article
T1 Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.
A1 Amo, Gemma
A1 García-Menaya, Jesús
A1 Campo, Paloma
A1 Cordobés, Concepción
A1 Plaza Serón, M Carmen
A1 Ayuso, Pedro
A1 Esguevillas, Gara
A1 Blanca, Miguel
A1 Agúndez, Jose A G
A1 García-Martín, Elena
K1 Alelos
K1 Asma
K1 Humanos
K1 Inmunoglobulina E
K1 Polimorfismo de nucleótido único
K1 Receptores de IgE
K1 Rinitis alérgica
AB Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
PB Nature Publishing Group
YR 2016
FD 2016-01-21
LK http://hdl.handle.net/10668/2400
UL http://hdl.handle.net/10668/2400
LA en
NO Amo G, García-Menaya J, Campo P, Cordobés C, Plaza Serón MC, Ayuso P, et al. A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels. Sci Rep. 2016; 6:19724
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025