RT Journal Article
T1 Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: results of a multicenter, controlled, randomized, open clinical trial.
A1 Argente, Jesús
A1 Gracia, Ricardo
A1 Ibáñez, Lourdes
A1 Oliver, Antonio
A1 Borrajo, Emilio
A1 Vela, Amaya
A1 López-Siguero, Juan Pedro
A1 Moreno, M Llanos
A1 Rodríguez-Hierro, Francisco
K1 Antropometría
K1 Estatura
K1 Determinación de la Edad por el Esqueleto
K1 Índice de Masa Corporal
K1 Preescolar
K1 Femenino
K1 Humanos
K1 Recién Nacido
K1 Crecimiento
K1 Hormona del Crecimiento
K1 Recién Nacido Pequeño para la Edad Gestacional
K1 Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
K1 Factor I del Crecimiento Similar a la Insulina
K1 Masculino
K1 Padres
AB CONTEXTGH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown.OBJECTIVEThe aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 months of treatment, compared with a control group without treatment during 12 months followed by 12 months of treatment, are shown.DESIGNWe performed a multicenter, controlled, randomized, open trial.SETTINGSThe pediatric endocrinology departments of 14 public hospitals in Spain participated in the study.PATIENTSSeventy-six children, aged 2-5 yr born SGA and without catch-up growth, were studied.INTERVENTIONChildren received GH at 0.06 mg/kg.d for 2 yr (group I) or were followed for 12 months with no treatment and then treated for 12 months (group II).MAIN OUTCOME MEASURESAge, general health status, pubertal stage, bone age, height, weight, biochemical and hormonal analyses, and adverse side effects were determined at biannual check-ups.RESULTSThe mean height sd score gain for chronological age in children treated for 24 months (group I) was 2.10, whereas in those treated only during the last 12 months (group II) was 1.43. In both groups, children under 4 yr of age had the greatest gain in growth velocity. No significant acceleration of bone age or side effects related to treatment was seen.CONCLUSIONVery young SGA children without spontaneous catch-up growth could benefit from GH treatment because growth was accelerated and no negative side effects were observed.
PB Endocrine Society
SN 0021-972X
YR 2007
FD 2007-08
LK http://hdl.handle.net/10668/549
UL http://hdl.handle.net/10668/549
LA en
NO Argente J, Gracia R, Ibáñez L, Oliver A, Borrajo E, Vela A, et al. Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: results of a multicenter, controlled, randomized, open clinical trial. J. Clin. Endocrinol. Metab.. 2007 Aug; 92(8):3095-101
NO Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't;
DS RISalud
RD Mar 14, 2025