RT Journal Article
T1 Assessment of the relationship between estimated cardiovascular risk and structural damage in patients with axial spondyloarthritis.
A1 Ladehesa-Pineda, María Lourdes
A1 Arias de la Rosa, Iván
A1 López Medina, Clementina
A1 Castro-Villegas, María Del Carmen
A1 Ábalos-Aguilera, María Del Carmen
A1 Ortega-Castro, Rafaela
A1 Gómez-García, Ignacio
A1 Seguí-Azpilcueta, Pedro
A1 Jiménez-Gómez, Yolanda
A1 Escudero-Contreras, Alejandro
A1 López Pedrera, Chary
A1 Barbarroja, Nuria
A1 Collantes-Estévez, Eduardo
A1 CASTRO Working Group, 
K1 axial spondyloarthritis
K1 cardiovascular risk
K1 carotid intima media thickness
K1 disease activity
K1 structural damage
AB To evaluate the association of estimated cardiovascular (CV) risk and subclinical atherosclerosis with radiographic structural damage in patients with axial spondyloarthritis (axSpA). Cross-sectional study including 114 patients axSpA from the SpA registry of Córdoba (CASTRO) and 132 age- and sex-matched healthy controls (HCs). Disease activity and the presence of traditional CV risk factors were recorded. The presence of atherosclerotic plaques and carotid intima media thickness (cIMT) were evaluated through carotid ultrasound and the SCORE index was calculated. Radiographic damage was measured though modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). The association between mSASSS and SCORE was tested using generalized linear models (GLM), and an age-adjusted cluster analysis was performed to identify different phenotypes dependent on the subclinical CV risk. Increased traditional CV risk factors, SCORE, and the presence of carotid plaques were found in axSpA patients compared with HCs. The presence of atherosclerotic plaques and SCORE were associated with radiographic structural damage. The GLM showed that the total mSASSS was associated independently with the SCORE [β coefficient 0.24; 95% confidence interval (CI) 0.10-0.38] adjusted for disease duration, age, tobacco, C-reactive protein, and non-steroidal anti-inflammatory drugs (NSAID) intake. Hard cluster analysis identified two phenotypes of patients. Patients from cluster 1, characterized by the presence of plaques and increased cIMT, had a higher prevalence of CV risk factors and SCORE, and more structural damage than cluster two patients. Radiographic structural damage is associated closely with increased estimated CV risk: higher SCORE levels in axSpA patients were found to be associated independently with mSASSS after adjusting for age, disease duration, CRP, tobacco and NSAID intake.
SN 1759-720X
YR 2020
FD 2020-12-30
LK https://hdl.handle.net/10668/28276
UL https://hdl.handle.net/10668/28276
LA en
DS RISalud
RD Apr 10, 2025