RT Journal Article
T1 Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
A1 Piñana, Jose Luis
A1 Xhaard, Alienor
A1 Tridello, Gloria
A1 Passweg, Jakob
A1 Kozijn, Anne
A1 Polverelli, Nicola
A1 Heras, Inmaculada
A1 Perez, Ariadna
A1 Sanz, Jaime
A1 Berghuis, Dagmar
A1 Vazquez, Lourdes
A1 Suarez-Lledo, Maria
A1 Itala-Remes, Maija
A1 Ozcelik, Tulay
A1 Iturrate Basaran, Isabel
A1 Karakukcu, Musa
A1 Al-Zahrani, Mohsen
A1 Choi, Goda
A1 Cuesta-Casas, Marian Angeles
A1 Batlle-Massana, Montserrat
A1 Viviana, Amato
A1 Blijlevens, Nicole
A1 Ganser, Arnold
A1 Kuskonmaz, Baris
A1 Labussiere-Wallet, Helene
A1 Shaw, Peter J
A1 Yegin, Zeynep Arzu
A1 Gonzalez-Vicent, Marta
A1 Rocha, Vanderson
A1 Ferster, Alina
A1 Knelange, Nina
A1 Navarro, David
A1 Mikulska, Malgorzata
A1 de-la-Camara, Rafael
A1 Styczynski, Jan
K1 Seasonal human coronavirus
K1 HCoV-229E
K1 HCoV-HKU1
K1 HCoV-NL63
K1 HCoV-OC43
K1 Allogeneic hematopoietic stem cell transplantation
K1 Community-acquired respiratory virus
K1 Immunocompromised
K1 Immunodeficiency score index
K1 Multiplex PCR assay
K1 Upper and lower respiratory tract disease
AB Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count  Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
PB Oxford University Press
YR 2020
FD 2020-08-29
LK http://hdl.handle.net/10668/16174
UL http://hdl.handle.net/10668/16174
LA en
NO Piñana JL, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, et al. Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. J Infect Dis. 2021 May 20;223(9):1564-1575
DS RISalud
RD Apr 17, 2025