%0 Journal Article
%A Piñana, Jose Luis
%A Xhaard, Alienor
%A Tridello, Gloria
%A Passweg, Jakob
%A Kozijn, Anne
%A Polverelli, Nicola
%A Heras, Inmaculada
%A Perez, Ariadna
%A Sanz, Jaime
%A Berghuis, Dagmar
%A Vazquez, Lourdes
%A Suarez-Lledo, Maria
%A Itala-Remes, Maija
%A Ozcelik, Tulay
%A Iturrate Basaran, Isabel
%A Karakukcu, Musa
%A Al-Zahrani, Mohsen
%A Choi, Goda
%A Cuesta-Casas, Marian Angeles
%A Batlle-Massana, Montserrat
%A Viviana, Amato
%A Blijlevens, Nicole
%A Ganser, Arnold
%A Kuskonmaz, Baris
%A Labussiere-Wallet, Helene
%A Shaw, Peter J
%A Yegin, Zeynep Arzu
%A Gonzalez-Vicent, Marta
%A Rocha, Vanderson
%A Ferster, Alina
%A Knelange, Nina
%A Navarro, David
%A Mikulska, Malgorzata
%A de-la-Camara, Rafael
%A Styczynski, Jan
%T Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
%D 2020
%U http://hdl.handle.net/10668/16174
%X Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count  Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.
%K Seasonal human coronavirus
%K HCoV-229E
%K HCoV-HKU1
%K HCoV-NL63
%K HCoV-OC43
%K Allogeneic hematopoietic stem cell transplantation
%K Community-acquired respiratory virus
%K Immunocompromised
%K Immunodeficiency score index
%K Multiplex PCR assay
%K Upper and lower respiratory tract disease
%~