RT Journal Article
T1 The urgent need to recover MHC class I in cancers for effective immunotherapy.
A1 Garrido, Federico
A1 Aptsiauri, Natalia
A1 Doorduijn, Elien M
A1 Garcia Lora, Angel M
A1 van Hall, Thorbald
AB Immune escape strategies aimed to avoid T-cell recognition, including the loss of tumor MHC class I expression, are commonly found in malignant cells. Tumor immune escape has proven to have a negative effect on the clinical outcome of cancer immunotherapy, including treatment with antibodies blocking immune checkpoint molecules. Hence, there is an urgent need to develop novel approaches to overcome tumor immune evasion. MHC class I antigen presentation is often affected in human cancers and the capacity to induce upregulation of MHC class I cell surface expression is a critical step in the induction of tumor rejection. This review focuses on characterization of rejection, escape, and dormant profiles of tumors and its microenvironment with a special emphasis on the tumor MHC class I expression. We also discuss possible approaches to recover MHC class I expression on tumor cells harboring reversible/'soft' or irreversible/'hard' genetic lesions. Such MHC class I recovery approaches might well synergize with complementary forms of immunotherapy.
YR 2016
FD 2016-01-18
LK http://hdl.handle.net/10668/9759
UL http://hdl.handle.net/10668/9759
LA en
DS RISalud
RD May 11, 2025