RT Journal Article
T1 Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction
A1 Ruiz-Limon, Patricia
A1 Ladehesa-Pineda, Maria L.
A1 Lopez-Medina, Clementina
A1 Lopez-Pedrera, Chary
A1 Abalos-Aguilera, Maria C.
A1 Barbarroja, Nuria
A1 Arias-Quiros, Isabel
A1 Perez-Sanchez, Carlos
A1 Arias-de la Rosa, Ivan
A1 Ortega-Castro, Rafaela
A1 Escudero-Contreras, Alejandro
A1 Collantes-Estevez, Eduardo
A1 Jimenez-Gomez, Yolanda
K1 Endothelium
K1 Circulating mononuclear cells
K1 Inflammation
K1 Oxidative stress
K1 Radiographic axial spondyloarthritis
K1 Endotelio
K1 Leucocitos mononucleares
K1 Inflamación
K1 Estrés oxidativo
K1 Espondiloartrite axial
AB Endothelial dysfunction (ED) is well known as a process that can lead to atherosclerosis and is frequently presented in radiographic axial spondyloarthritis (r-axSpA) patients. Here, we investigated cellular and molecular mechanisms underlying r-axSpA-related ED, and analyzed the potential effect of peripheral blood mononuclear cells (PBMCs) in promoting endothelial injury in r-axSpA. A total of 30 r-axSpA patients and 32 healthy donors (HDs) were evaluated. The endothelial function, inflammatory and atherogenic profile, and oxidative stress were quantified. In vitro studies were designed to evaluate the effect of PBMCs from r-axSpA patients on aberrant endothelial activation. Compared to HDs, our study found that, associated with ED and the plasma proatherogenic profile present in r-axSpA, PBMCs from these patients displayed a pro-oxidative, proinflammatory, and proatherogenic phenotype, with most molecular changes noticed in lymphocytes. Correlation studies revealed the relationship between this phenotype and the microvascular function. Additional in vitro studies confirmed that PBMCs from r-axSpA patients promoted endothelial injury. Altogether, this study suggests the relevance of r-axSpA itself as a strong and independent cardiovascular risk factor, contributing to a dysfunctional endothelium and atherogenic status by aberrant activation of PBMCs. Lymphocytes could be the main contributors in the development of ED and subsequent atherosclerosis in this pathology.
PB MDPI
YR 2021
FD 2021-06-04
LK http://hdl.handle.net/10668/4219
UL http://hdl.handle.net/10668/4219
LA en
NO Ruiz-Limon P, Ladehesa-Pineda ML, Lopez-Medina C, Lopez-Pedrera C, Abalos-Aguilera MC, Barbarroja N, et al. Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction. Diagnostics. 2021 Jun 4;11(6):1037
DS RISalud
RD Mar 14, 2025