RT Journal Article
T1 A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
A1 Ríos-Tamayo, Rafael
A1 Lupiañez, Carmen Belén
A1 Campa, Daniele
A1 Hielscher, Thomas
A1 Weinhold, Niels
A1 Martínez-López, Joaquin
A1 Jerez, Andrés
A1 Landi, Stefano
A1 Jamroziak, Krzysztof
A1 Dumontet, Charles
A1 Wątek, Marzena
A1 Lesueur, Fabienne
A1 Reis, Rui Manuel
A1 Marques, Herlander
A1 Jurczyszyn, Artur
A1 Vogel, Ulla
A1 Buda, Gabriele
A1 García-Sanz, Ramón
A1 Orciuolo, Enrico
A1 Petrini, Mario
A1 Vangsted, Annette J
A1 Gemignani, Federica
A1 Försti, Asta
A1 Goldschmidt, Hartmut
A1 Hemminki, Kari
A1 Canzian, Federico
A1 Jurado, Manuel
A1 Sainz, Juan
K1 diabetes
K1 genetic variants
K1 multiple myeloma
K1 survival
AB Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.
YR 2016
FD 2016
LK http://hdl.handle.net/10668/10290
UL http://hdl.handle.net/10668/10290
LA en
DS RISalud
RD Apr 9, 2025