RT Journal Article
T1 Recent Progress in Gene Therapy for Ovarian Cancer.
A1 Ayen, Angela
A1 Jimenez Martinez, Yaiza
A1 Marchal, Juan A
A1 Boulaiz, Houria
K1 delivery systems
K1 gene therapy
K1 ovarian cancer
K1 ovarian cancer stem cells
K1 promoter
K1 suicide genes
AB Ovarian cancer is the most lethal gynecological malignancy in developed countries. This is due to the lack of specific symptoms that hinder early diagnosis and to the high relapse rate after treatment with radical surgery and chemotherapy. Hence, novel therapeutic modalities to improve clinical outcomes in ovarian malignancy are needed. Progress in gene therapy has allowed the development of several strategies against ovarian cancer. Most are focused on the design of improved vectors to enhance gene delivery on the one hand, and, on the other hand, on the development of new therapeutic tools based on the restoration or destruction of a deregulated gene, the use of suicide genes, genetic immunopotentiation, the inhibition of tumour angiogenesis, the alteration of pharmacological resistance, and oncolytic virotherapy. In the present manuscript, we review the recent advances made in gene therapy for ovarian cancer, highlighting the latest clinical trials experience, the current challenges and future perspectives.
PB MDPI AG
YR 2018
FD 2018-06-27
LK http://hdl.handle.net/10668/12667
UL http://hdl.handle.net/10668/12667
LA en
NO Áyen Á, Jiménez Martínez Y, Marchal JA, Boulaiz H. Recent Progress in Gene Therapy for Ovarian Cancer. Int J Mol Sci. 2018 Jun 30;19(7):1930.
NO : This research was supported by the Fundación Mutua Madrileña by the proyect FMM-AP16683-2017,Consejería de Salud Junta de Andalucía (PI-0089-2017) and from the Chair “Doctors Galera-Requena in cancerstem cell research”
DS RISalud
RD Apr 10, 2025