RT Journal Article
T1 Signaling pathways involved in colorectal cancer progression.
A1 Koveitypour, Zahra
A1 Panahi, Farnoush
A1 Vakilian, Mehrdad
A1 Peymani, Maryam
A1 Seyed Forootan, Farzad
A1 Nasr Esfahani, Mohammad Hossein
A1 Ghaedi, Kamran
K1 Colorectal cancer
K1 EGFR
K1 MAPK
K1 Notch
K1 TGF-β
AB Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus on the mitogen-activated protein kinase (MAPK) cascades downstream of the epidermal growth factor receptor (EGFR), Notch, PI3K/AKT pathway, transforming growth factor-β (TGF-β), and Wnt signaling pathways. Various mutations in the components of these signaling pathways have been linked to the development of CRC. Accordingly, numerous efforts have been carried out to target the signaling pathways to develop novel therapeutic approaches. Herein, we review the signaling pathways involved in the incidence and progression of CRC, and the strategies for the therapy targeting components of signaling pathways in CRC.
SN 2045-3701
YR 2019
FD 2019-12-02
LK http://hdl.handle.net/10668/14816
UL http://hdl.handle.net/10668/14816
LA en
DS RISalud
RD May 11, 2025