RT Journal Article
T1 Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization.
A1 Smith, Caren E
A1 Coltell, Oscar
A1 Sorlí, Jose V
A1 Estruch, Ramón
A1 Martínez-González, Miguel Ángel
A1 Salas-Salvadó, Jordi
A1 Fitó, Montserrat
A1 Arós, Fernando
A1 Dashti, Hassan S
A1 Lai, Chao Q
A1 Miró, Leticia
A1 Serra-Majem, Lluís
A1 Gómez-Gracia, Enrique
A1 Fiol, Miquel
A1 Ros, Emilio
A1 Aslibekyan, Stella
A1 Hidalgo, Bertha
A1 Neuhouser, Marian L
A1 Di, Chongzhi
A1 Tucker, Katherine L
A1 Arnett, Donna K
A1 Ordovás, José M
A1 Corella, Dolores
AB Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.
YR 2016
FD 2016-09-14
LK http://hdl.handle.net/10668/10443
UL http://hdl.handle.net/10668/10443
LA en
DS RISalud
RD Apr 6, 2025