RT Journal Article
T1 Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties.
A1 Vezza, Teresa
A1 Garrido-Mesa, Jose
A1 Diez-Echave, Patricia
A1 Hidalgo-Garcia, Laura
A1 Ruiz-Malagon, Antonio J
A1 Garcia, Federico
A1 Sanchez, Manuel
A1 Toral, Marta
A1 Romero, Miguel
A1 Duarte, Juan
A1 Guillamon, Enrique
A1 Baños Arjona, Alberto
A1 Moron, Rocio
A1 Galvez, Julio
A1 Rodriguez-Nogales, Alba
A1 Rodriguez-Cabezas, María Elena
K1 cytokines
K1 dysbiosis
K1 glucose metabolism
K1 lipid metabolism
K1 microbiota
K1 obesity
K1 organosulfur compound
AB Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.
PB MDPI AG
YR 2021
FD 2021-07-25
LK http://hdl.handle.net/10668/18452
UL http://hdl.handle.net/10668/18452
LA en
NO Vezza T, Garrido-Mesa J, Diez-Echave P, Hidalgo-García L, Ruiz-Malagón AJ, García F, Sánchez M, et al.  Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients. 2021 Jul 28;13(8):2595.
NO This research was funded by the FEDER-INNTERCONECTA-CDTI program (CDTI, Centrefor the Development of Industrial Technology; NATURPICK Project ITC-20181038), by the Juntade Andalucía (CTS 164) and by Instituto de Salud Carlos III (PI19/01058) with funds from theEuropean Union. T.V. is a postdoctoral fellow from Instituto de Investigación Biosanitaria de Granada;A.J.R.-M. and L.H.-G. are predoctoral fellows from University of Granada (“Programa de Doctorado:Medicina Clínica y Salud Pública”); P.D.-E. is a postdoctoral fellow from University of Granada. TheCIBER-EHD and CIBERCV are funded by the Instituto de Salud Carlos III.
DS RISalud
RD Apr 8, 2025