RT Journal Article
T1 Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study.
A1 Chajès, Véronique
A1 Biessy, Carine
A1 Ferrari, Pietro
A1 Romieu, Isabelle
A1 Freisling, Heinz
A1 Huybrechts, Inge
A1 Scalbert, Augustin
A1 Bueno de Mesquita, Bas
A1 Romaguera, Dora
A1 Gunter, Marc J
A1 Vineis, Paolo
A1 Hansen, Camilla Plambeck
A1 Jakobsen, Marianne Uhre
A1 Clavel-Chapelon, Françoise
A1 Fagherazzi, Guy
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verana
A1 Neamat-Allah, Jasmine
A1 Boeing, Heiner
A1 Bachlechner, Ursula
A1 Trichopoulou, Antonia
A1 Naska, Androniki
A1 Orfanos, Philippos
A1 Pala, Valeria
A1 Masala, Giovanna
A1 Mattiello, Amalia
A1 Skeie, Guri
A1 Weiderpass, Elisabete
A1 Agudo, Antonio
A1 Huerta, Jose Maria
A1 Ardanaz, Eva
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Quirós, Jose Ramon
A1 Johansson, Ingegerd
A1 Winkvist, Anna
A1 Sonested, Emily
A1 Key, Tim
A1 Khaw, Kay-Tee
A1 Wareham, Nicolas J
A1 Peeters, Petra H M
A1 Slimani, Nadia
K1 Marcadores biológicos
K1 Peso corporal
K1 Dieta
K1 Estudios epidemiológicos
K1 Ácidos grasos
K1 Neoplasias
K1 Estado Nutricional
K1 Ácidos Oléicos
AB BACKGROUNDFew epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODSBaseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region.RESULTSIn women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend<.0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss (OR = 0.82, 95% CI = 0.66-1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5-year follow-up (OR = 1.08, 95% CI = 0.88-1.33, p = 0.454). No association was found for saturated and cis-monounsaturated fatty acids.CONCLUSIONSThese data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially-produced trans fatty acids.
PB Public Library of Science
YR 2015
FD 2015-02-12
LK http://hdl.handle.net/10668/1969
UL http://hdl.handle.net/10668/1969
LA en
NO Chajès V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I, et al. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. PLoS ONE 2015; 10(2):e0118206
NO Journal Article;
DS RISalud
RD Apr 5, 2025