RT Journal Article
T1 Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial.
A1 Papadaki, Angeliki
A1 Martínez-González, Miguel Ángel
A1 Alonso-Gómez, Angel
A1 Rekondo, Javier
A1 Salas-Salvadó, Jordi
A1 Corella, Dolores
A1 Ros, Emilio
A1 Fitó, Montse
A1 Estruch, Ramon
A1 Lapetra, José
A1 García-Rodriguez, Antonio
A1 Fiol, Miquel
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Ruiz-Canela, Miguel
A1 Bulló, Monica
A1 Serra-Mir, Mercè
A1 Sorlí, Jose V
A1 Arós, Fernando
K1 Cardiovascular disease
K1 Heart failure
K1 Mediterranean diet
K1 PREDIMED study
AB The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. ISRCTN35739639.
YR 2017
FD 2017-01-30
LK http://hdl.handle.net/10668/10817
UL http://hdl.handle.net/10668/10817
LA en
DS RISalud
RD Apr 11, 2025