RT Journal Article
T1 The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
A1 Campa, Daniele
A1 Hüsing, Anika
A1 McKay, James D
A1 Sinilnikova, Olga
A1 Vogel, Ulla
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Stegger, Jakob
A1 Clavel-Chapelon, Françoise
A1 Chabbert-Buffet, Nathalie
A1 Fagherazzi, Guy
A1 Trichopoulou, Antonia
A1 Zylis, Dimosthenis
A1 Oustoglou, Erifili
A1 Rohrmann, Sabine
A1 Teucher, Birgit
A1 Fisher, Eva
A1 Boeing, Heiner
A1 Masala, Giovanna
A1 Krogh, Vittorio
A1 Sacerdote, Carlota
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Onland-Moret, Charlotte
A1 van Gils, Carla H
A1 Bueno de Mesquita, H Bas
A1 Lund, Eiliv
A1 Chirlaque, María D
A1 Sala, Nuria
A1 Quirós, José R
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Molina-Montes, Esther
A1 Hallmans, Göran
A1 Lenner, Per
A1 Travis, Ruth C
A1 Key, Timothy J
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Rinaldi, Sabina
A1 Slimani, Nadia
A1 Chajes, Veronique
A1 Siddiq, Afshan
A1 Riboli, Elio
A1 Kaaks, Rudolf
A1 Canzian, Federico
K1 Neoplasias de la mama
K1 Índice de masa muscular
K1 Polimorfismo Genético
K1 Estudio de Asociación del Genoma Completo
K1 Estudios de cohortes
AB BackgroundThe single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methodswe tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and ConclusionsIn this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
PB Biomed Central
YR 2010
FD 2010-10-18
LK http://hdl.handle.net/10668/278
UL http://hdl.handle.net/10668/278
LA en
NO Campa D, Hüsing A, McKay JD, Sinilnikova O, Vogel U, Tjønneland A, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer. 2010 Oct 18; 10:563
DS RISalud
RD Apr 8, 2025