RT Journal Article
T1 Association between metabolic syndrome and uric acid: a systematic review and meta-analysis.
A1 Raya-Cano, Elena
A1 Vaquero-Abellan, Manuel
A1 Molina-Luque, Rafael
A1 De Pedro-Jimenez, Domingo
A1 Molina-Recio, Guillermo
A1 Romero-Saldaña, Manuel
AB This systematic review and meta-analysis aim to provide the best evidence on the association between metabolic syndrome (MetS) and uric acid (UA) by determining the size of the efect of this biomarker on MetS. The review protocol is registered with PROSPERO (CRD42021231124). The searchcovered the PubMed and Scopus databases. Methodological quality was assessed with the STROBE tool, overall risk of bias with RevMan (Cochrane Collaboration) and quality of evidence with Grade Pro. Initially, 1582 articles were identifed. Then, after excluding duplicates and reviewing titles andabstracts, 1529 articles were excluded from applying the eligibility criteria. We included 43 papers (56 groups) comparing UA concentrations between subjects 91,845 with MetS and 259,931 controls. Subjects with MetS had a higher mean UA of 0.57 mg/dl (95% CI 0.54–0.61) (p< 0.00001). Given theheterogeneity of the included studies, the researchers decided to perform subgroups analysis. Men with MetS have a higher UA concentration mg/dl 0.53 (95% CI 0.45–0.62, p< 0.00001) and women with MetS 0.57 (95% CI 0.48–0.66, p < 0.00001) compared to subjects without MetS. Assessment ofUA concentration could provide a new avenue for early diagnosis of MetS, as a new biomarker and the possibility of new therapeutic targets.
PB Nature Publishing Group
YR 2022
FD 2022-10-07
LK http://hdl.handle.net/10668/19628
UL http://hdl.handle.net/10668/19628
LA en
NO Raya-Cano E, Vaquero-Abellán M, Molina-Luque R, De Pedro-Jiménez D, Molina-Recio G, Romero-Saldaña M. Association between metabolic syndrome and uric acid: a systematic review and meta-analysis. Sci Rep. 2022 Nov 1;12(1):18412
DS RISalud
RD Apr 7, 2025