RT Journal Article
T1 Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea
A1 Campos-Rodriguez, Francisco
A1 Gonzalez-Martinez, Monica
A1 Sanchez-Armengol, Angeles
A1 Jurado-Gamez, Bernabe
A1 Cordero-Guevara, Jose
A1 Reyes-Nunez, Nuria
A1 Troncoso, Maria F.
A1 Abad-Fernandez, Araceli
A1 Teran-Santos, Joaquin
A1 Caballero-Rodriguez, Julian
A1 Martin-Romero, Mercedes
A1 Encabo-Motino, Ana
A1 Sacristan-Bou, Lirios
A1 Navarro-Esteva, Javier
A1 Somoza-Gonzalez, Maria
A1 Masa, Juan F.
A1 Sanchez-Quiroga, Maria A.
A1 Jara-Chinarro, Beatriz
A1 Orosa-Bertol, Belen
A1 Martinez-Garcia, Miguel A.
A1 Spanish Sleep Network, 
K1 Gender-differences
K1 Metaanalysis
K1 Cpap
K1 Sex
K1 Hypertension
K1 Impact
K1 Risk
K1 Osa
K1 Association
K1 Management
AB Continuous positive airway pressure (CPAP) reduces blood pressure levels in hypertensive patients with obstructive sleep apnoea (OSA). However, the role of CPAP in blood pressure and the metabolic profile in women has not yet been assessed. In this study we investigated the effect of CPAP on blood pressure levels and the glucose and lipid profile in women with moderate-to-severe OSA.A multicentre, open-label, randomised controlled trial was conducted in 307 women diagnosed with moderate-to-severe OSA (apnoea-hypopnoea index >= 15 events.h(-1)) in 19 Spanish Sleep Units. Women were randomised to CPAP (n=151) or conservative treatment (n=156) for 12 weeks. Changes in office blood pressure measures as well as in the glucose and lipid profile were assessed in both groups.Compared with the control group, the CPAP group achieved a significantly greater decrease in diastolic blood pressure (-2.04 mmHg, 95% CI -4.02--0.05; p=0.045), and a nonsignificantly greater decrease in systolic blood pressure (-1.54 mmHg, 95% CI -4.58-1.51; p=0.32) and mean blood pressure (-1.90 mmHg, 95% CI -4.0-0.31; p=0.084). CPAP therapy did not change any of the metabolic variables assessed.In women with moderate-to-severe OSA, 12 weeks of CPAP therapy improved blood pressure, especially diastolic blood pressure, but did not change the metabolic profile, compared with conservative treatment.
PB European respiratory soc journals ltd
SN 0903-1936
YR 2017
FD 2017-08-01
LK http://hdl.handle.net/10668/19112
UL http://hdl.handle.net/10668/19112
LA en
DS RISalud
RD Apr 10, 2025