RT Journal Article
T1 Adipose tissue gene expression of factors related to lipid processing in obesity.
A1 Clemente-Postigo, Mercedes
A1 Queipo-Ortuño, María Isabel
A1 Fernández-García, Diego José
A1 Gómez-Huelgas, Ricardo
A1 Tinahones, Francisco J
A1 Cardona Díaz, Fernando
K1 LRP1 protein, human
K1 acylation stimulating protein, human
K1 Proteínas de Unión a Ácidos Grasos
K1 Índice de masa corporal
K1 Diabetes Mellitus Tipo 2
K1 FABP4 protein, human
K1 Expresión genética
K1 Resistencia a la insulina
K1 Péptidos y Proteínas de Señalización Intercelular
K1 Grasa intraabdominal
K1 Metabolismo de los Lípidos
K1 Lipoproteína Lipasa
K1 Proteina 1 Relacionada con Receptor de Lipoproteína de Baja Densidad
K1 Obesidad mórbida
K1 Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
K1 Grasa subcutánea
AB BACKGROUNDAdipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid storage. The aim of this study was to analyze the gene expression of factors involved in lipid uptake and processing in subcutaneous (SAT) and visceral (VAT) adipose tissue according to body mass index (BMI) and the degree of insulin resistance (IR).METHODS AND PRINCIPAL FINDINGSVLDL receptor (VLDLR), lipoprotein lipase (LPL), acylation stimulating protein (ASP), LDL receptor-related protein 1 (LRP1) and fatty acid binding protein 4 (FABP4) gene expression was measured in VAT and SAT from 28 morbidly obese patients with Type 2 Diabetes Mellitus (T2DM) or high IR, 10 morbidly obese patients with low IR, 10 obese patients with low IR and 12 lean healthy controls. LPL, FABP4, LRP1 and ASP expression in VAT was higher in lean controls. In SAT, LPL and FABP4 expression were also higher in lean controls. BMI, plasma insulin levels and HOMA-IR correlated negatively with LPL expression in both VAT and SAT as well as with FABP4 expression in VAT. FABP4 gene expression in SAT correlated inversely with BMI and HOMA-IR. However, multiple regression analysis showed that BMI was the main variable contributing to LPL and FABP4 gene expression in both VAT and SAT.CONCLUSIONSMorbidly obese patients have a lower gene expression of factors related with lipid uptake and processing in comparison with healthy lean persons.
PB Public Library of Science
YR 2011
FD 2011-09-22
LK http://hdl.handle.net/10668/694
UL http://hdl.handle.net/10668/694
LA en
NO Clemente-Postigo M, Queipo-Ortuño MI, Fernandez-Garcia DJ, Gomez-Huelgas R, Tinahones Madueño FJ, Cardona Díaz F. Adipose tissue gene expression of factors related to lipid processing in obesity. PLoS ONE; 6(9):e24783
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025