RT Journal Article
T1 Long-term effect of 2 intensive statin regimens on treatment and incidence of cardiovascular events in familial hypercholesterolemia: The SAFEHEART study.
A1 Perez de Isla, Leopoldo
A1 Arroyo-Olivares, Raquel
A1 Muñiz-Grijalvo, Ovidio
A1 Diaz-Diaz, Jose Luis
A1 Zambon, Daniel
A1 Fuentes, Francisco
A1 Sanchez Muñoz-Torrero, Juan F
A1 Mediavilla, Juan Diego
A1 Gonzalez-Estrada, Aurora
A1 Miramontes-Gonzalez, Jose Pablo
A1 de Andres, Raimundo
A1 Mauri, Marta
A1 Mosquera, Daniel
A1 Cepeda, Jose M
A1 Suarez, Lorena
A1 Barba-Romero, Miguel Angel
A1 Argüeso, Rosa
A1 Alvarez-Baños, Pilar
A1 Michan, Alfredo
A1 Romero-Jimenez, Manuel J
A1 Garcia-Cruces, Jesus
A1 Padro, Teresa
A1 Alonso, Rodrigo
A1 Mata, Pedro
K1 Atorvastatin
K1 Familial hypercholesterolemia
K1 Long-term prognosis
K1 Rosuvastatin
AB Maximal doses of potent statins are the basement of treatment of familial hypercholesterolemia (FH). Little is known about the use of different statin regimens in FH. The objectives of the study were to describe the treatment changes and low-density lipoprotein cholesterol (LDL-C) goal achievement with atorvastatin (ATV) and rosuvastatin (RV) in the SAFEHEART cohort, as well as to analyze the incidence of atherosclerotic cardiovascular events (ACVEs) and changes in the cardiovascular risk. SAFEHEART is a prospective follow-up nationwide cohort study in a molecularly defined FH population. The patients were contacted on a yearly basis to obtain relevant changes in life habits, medication, and ACVEs. A total of 1939 patients were analyzed. Median follow-up was 6.6 years (5-10). The estimated 10-year risk according the SAFEHEART risk equation was 1.61 (0.67-3.39) and 1.22 (0.54-2.93) at enrollment for ATV and RV, respectively (P  ATV and RV are 2 high-potency statins widely used in FH. Although the reduction in LDL-C levels was greater with RV than with ATV, the superiority of RV for reducing ACVEs was not demonstrated.
PB Elsevier Inc.
SN 1933-2874
YR 2019
FD 2019-10-03
LK http://hdl.handle.net/10668/14664
UL http://hdl.handle.net/10668/14664
LA en
NO Pérez de Isla L, Arroyo-Olivares R, Muñiz-Grijalvo O, Diaz-Díaz JL, Zambón D, Fuentes F, et al. Long-term effect of 2 intensive statin regimens on treatment and incidence of cardiovascular events in familial hypercholesterolemia: The SAFEHEART study. J Clin Lipidol. 2019 Nov-Dec;13(6):989-996.
NO This study was supported by Fundaci on HipercolesterolemiaFamiliar; Grant G03/181 and FIS PI12/01289 from Instituto de Salud Carlos III (ISCIII), Grant 08-2008 Centro Nacional de Investigaci on Cardiovascular (CNIC).
DS RISalud
RD Apr 8, 2025