RT Journal Article
T1 Near-normal aerobic capacity in long-term survivors after lung transplantation.
A1 Saez-Gimenez, Berta
A1 Barrecheguren, Miriam
A1 Ramon, Maria Antònia
A1 Gomez-Garrido, Alba
A1 Bravo, Carlos
A1 Monforte, Víctor
A1 López-Meseguer, Manuel
A1 Berastegui, Cristina
A1 Revilla, Eva
A1 Romero, Christian
A1 Laporta, Rosalía
A1 Fernández-Rozas, Sonia
A1 Redel-Montero, Javier
A1 Solé, Amparo
A1 de la Torre, Mercedes
A1 Puente, Luis
A1 Roman, Antonio
A1 Gómez-Ollés, Susana
A1 Ojanguren, Iñigo
AB The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives. The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity. This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET). 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V'O2 ) had a mean±sd value of 21.49±6.68 mL·kg-1·min-1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V'O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25-75th percentile) EuroQol-5D score was 1 (0.95-1), indicating a good quality of life. The median (25-75th percentile) International Physical Activity Questionnaire score was 5497 (4007-9832) MET-min·week-1 with 89% of patients reporting more than 1500 MET-min·week-1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V'O2max (mL·kg-1·min-1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders. We report for the first time near-normal peak V'O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.
SN 2312-0541
YR 2021
FD 2021-02-01
LK https://hdl.handle.net/10668/25782
UL https://hdl.handle.net/10668/25782
LA en
DS RISalud
RD Apr 7, 2025