RT Journal Article
T1 Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State
A1 Sánchez-González, Cristina
A1 Rivas-García, Lorenzo
A1 Rodríguez-Nogales, Alba
A1 Algieri, Francesca
A1 Gálvez, Julio
A1 Aranda, Pilar
A1 Montes-Bayón, María
A1 Llopis, Juan
K1 Vanadium
K1 Hepcidin
K1 Inflammation
K1 Anemia
K1 Diabetes
K1 Rats
K1 Iron
K1 mRNA
K1 Intestinal absorption
K1 Gene expression
K1 Vanadio
K1 Hepcidin
K1 Inflamación
K1 Ratas
K1 Hierro
K1 ARN mensajero
K1 Absorción intestinal
K1 Expresión génica
AB Diabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.
PB MDPI
YR 2021
FD 2021-04-11
LK http://hdl.handle.net/10668/4379
UL http://hdl.handle.net/10668/4379
LA en
NO Sánchez-González C, Rivas-García L, Rodríguez-Nogales A, Algieri F, Gálvez J, Aranda P, et al. Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State. Nutrients. 2021 Apr 11;13(4):1256
DS RISalud
RD Apr 9, 2025