%0 Journal Article
%A Navas Alcántara, María Sierra
%A Montero Rivas, Lorena
%A Guisado Espartero, María Esther
%A Rubio-Rivas, Manuel
%A Ayuso García, Blanca
%A Moreno Martinez, Francisco
%A Ausín García, Cristina
%A Taboada Martínez, María Luisa
%A Arnalich Fernández, Francisco
%A Martínez Murgui, Raúl
%A Molinos Castro, Sonia
%A Ramos Muñoz, Maria Esther
%A Fernández-Garcés, Mar
%A Carreño Hernandez, Mari Cruz
%A García García, Gema María
%A Vázquez Piqueras, Nuria
%A Abadía-Otero, Jesica
%A Lajara Villar, Lourdes
%A Salazar Monteiro, Cristina
%A Pascual Pérez, María de Los Reyes
%A Perez-Martin, Santiago
%A Collado-Aliaga, Javier
%A Antón-Santos, Juan-Miguel
%A Lumbreras-Bermejo, Carlos
%A en nombre del grupo SEMI-COVID-19
%T Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registry.
%D 2021
%U http://hdl.handle.net/10668/22369
%X Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19). Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality. The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events. Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.
%K COVID-19
%K Hospitalizado
%K Hospitalized
%K Mortalidad
%K Mortality
%K SARS-CoV-2
%K Smoking
%K Tabaquismo
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