RT Journal Article T1 From Food to Genes: Transcriptional Regulation of Metabolism by Lipids and Carbohydrates. A1 Bravo-Ruiz, Ines A1 Medina, Miguel Angel A1 Martinez-Poveda, Beatriz K1 ChREBP K1 Mondo K1 PPAR K1 lipid and glucose metabolism K1 macronutrient sensing K1 nutrigenomics K1 transcriptional regulation AB Lipids and carbohydrates regulate gene expression by means of molecules that sense these macronutrients and act as transcription factors. The peroxisome proliferator-activated receptor (PPAR), activated by some fatty acids or their derivatives, and the carbohydrate response element binding protein (ChREBP), activated by glucose-derived metabolites, play a key role in metabolic homeostasis, especially in glucose and lipid metabolism. Furthermore, the action of both factors in obesity, diabetes and fatty liver, as well as the pharmacological development in the treatment of these pathologies are indeed of high relevance. In this review we present an overview of the discovery, mechanism of activation and metabolic functions of these nutrient-dependent transcription factors in different tissues contexts, from the nutritional genomics perspective. The possibility of targeting these factors in pharmacological approaches is also discussed. Lipid and carbohydrate-dependent transcription factors are key players in the complex metabolic homeostasis, but these factors also drive an adaptive response to non-physiological situations, such as overeating. Possibly the decisive role of ChREBP and PPAR in metabolic regulation points to them as ideal therapeutic targets, but their pleiotropic functions in different tissues makes it difficult to "hit the mark". YR 2021 FD 2021-04-30 LK http://hdl.handle.net/10668/17744 UL http://hdl.handle.net/10668/17744 LA en NO This work was supported by grants PID2019-105010RB-100 (Spanish Ministry of Science), UMA18-FEDERJA-220 (Andalusian Government and FEDER), and funds from group BIO 267 (Andalusian Government). The authors thank “Plan Propio de Investigación y Transferencia” (Universityof Málaga) for their “Iniciación a la Investigación” fellowship, supporting Inés Bravo-Ruiz. The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Cardiovasculares” are initiatives from the ISCIII (Spain). DS RISalud RD Apr 17, 2025