RT Journal Article
T1 Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus
A1 Ferrera-Suanzes, Marta
A1 Prieto, Victoria
A1 Medina-Olivera, Antonio J.
A1 Botubol-Ares, José Manuel
A1 Galán-Sánchez, Fátima
A1 Rodríguez-Iglesias, Manuel A.
A1 Hernández-Galán, Rosario
A1 Durán-Peña, María Jesús
K1 Degraded limonoids
K1 Drug design
K1 S. aureus
K1 MRSA
K1 Drug-like properties
K1 Methicillin-resistant staphylococcus aureus
K1 Staphylococcus aureus
K1 Diseño de fármacos
K1 Staphylococcus aureus resistente a meticilina
AB Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) have become serious infections in humans and ruminants. S. aureus strains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In the continuous fierce fight against the emergent multi-drug resistant bacterial strains, straightforward and scalable synthetic procedures to produce new active molecules are in demand. Analysis of molecular properties points to degraded limonoids as promising candidates. In this article, we report a simple synthetic approach to obtain degraded limonoid analogs as scaffolds for new antibacterial molecules. The minimum inhibitory concentrations against S. aureus were evaluated for the stereoisomer mixtures by the broth microdilution method. Analysis of results showed that the acetylated derivatives were the most active of them all.
PB MDPI
YR 2020
FD 2020-08-06
LK http://hdl.handle.net/10668/4303
UL http://hdl.handle.net/10668/4303
LA en
NO Ferrera-Suanzes M, Prieto V, Medina-Olivera AJ, Botubol-Ares JM, Galán-Sánchez F, Rodríguez-Iglesias MA, et al. Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus. Antibiotics. 2020 Aug 6;9(8):488
DS RISalud
RD Apr 11, 2025