TY  - JOUR
AU  - Zatreanu, Diana
AU  - Han, Zhong
AU  - Mitter, Richard
AU  - Tumini, Emanuela
AU  - Williams, Hannah
AU  - Gregersen, Lea
AU  - Dirac-Svejstrup, A Barbara
AU  - Roma, Stefania
AU  - Stewart, Aengus
AU  - Aguilera, Andres
AU  - Svejstrup, Jesper Q
PY  - 2019
DO  - 10.1016/j.molcel.2019.07.037
UR  - http://hdl.handle.net/10668/14507
T2  - Molecular cell
AB  - Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood. Here, we used a mutant version of the...
LA  - en
KW  - 53BP1
KW  - DNA-RNA hybrids
KW  - R-loops
KW  - RNA polymerase II
KW  - TFIIS
KW  - backtracking
KW  - transcript cleavage
KW  - transcript elongation
KW  - transcription-associated genome instability
KW  - Cell Line, Tumor
KW  - Genomic Instability
KW  - HEK293 Cells
KW  - Humans
KW  - Mutation
KW  - R-Loop Structures
KW  - RNA Polymerase II
KW  - RNA Splicing
KW  - RNA, Messenger
KW  - Stress, Physiological
KW  - Structure-Activity Relationship
KW  - Transcription, Genetic
KW  - Transcriptional Elongation Factors
TI  - Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.
TY  - research article
VL  - 76
ER  -