RT Journal Article
T1 Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study.
A1 Márquez-Rodas, Iván
A1 Martín González, Manuel
A1 Nagore, Eduardo
A1 Gómez-Fernández, Cristina
A1 Avilés-Izquierdo, Jose Antonio
A1 Maldonado-Seral, Cayetana
A1 Soriano, Virtudes
A1 Majem-Tarruella, Margarita
A1 Palomar, Virginia
A1 Maseda, Rocio
A1 Martín-Carnicero, Alfonso
A1 Puertolas, Teresa
A1 Godoy, Elena
A1 Cerezuela, Pablo
A1 Ochoa de Olza, Maria
A1 Campos, Begoña
A1 Perez-Ruiz, Elisabeth
A1 Soria, Ainara
A1 Gil-Arnaiz, Irene
A1 Gonzalez-Cao, Maria
A1 Galvez, Elisa
A1 Arance, Ana
A1 Belon, Joaquin
A1 Cruz-Merino, Luis de la
A1 Martín-Algarra, Salvador
K1 Melanoma
K1 Risk factor
K1 Family history
K1 Multiple melanoma
K1 Amilial melanoma patients
K1 Dermatología
K1 Mitosis
K1 Neoplasias Pancreáticas
K1 Pronóstico
K1 Factores de Riesgo
K1 Quemadura Solar
AB INTRODUCTIONFamilial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain.PATIENTS AND METHODSAn observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments.RESULTSIn all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups.CONCLUSIONSSimilar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.
PB Public Library of Science
YR 2015
FD 2015-04-13
LK http://hdl.handle.net/10668/1964
UL http://hdl.handle.net/10668/1964
LA en
NO Márquez-Rodas I, Martín González M, Nagore E, Gómez-Fernández C, Avilés-Izquierdo JA, Maldonado-Seral C, et al. Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study. PLoS ONE. 2015; 10(4):e0124239
NO Journal Article;
DS RISalud
RD Apr 8, 2025