TY  - JOUR
AU  - Gamiz-Arco, Gloria
AU  - Gutierrez-Rus, Luis I
AU  - Risso, Valeria A
AU  - Ibarra-Molero, Beatriz
AU  - Hoshino, Yosuke
AU  - Petrović, Dušan
AU  - Justicia, Jose
AU  - Cuerva, Juan Manuel
AU  - Romero-Rivera, Adrian
AU  - Seelig, Burckhard
AU  - Gavira, Jose A
AU  - Kamerlin, Shina C L
AU  - Gaucher, Eric A
AU  - Sanchez-Ruiz, Jose M
PY  - 2021
DO  - 10.1038/s41467-020-20630-1
UR  - http://hdl.handle.net/10668/16985
T2  - Nature communications
AB  - Glycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional properties of a putative ancestor of bacterial and eukaryotic family-1 glycosidases. The ancestral...
LA  - en
KW  - Allosteric Regulation
KW  - Amino Acid Sequence
KW  - Bacteria
KW  - Crystallography, X-Ray
KW  - Eukaryota
KW  - Glycoside Hydrolases
KW  - Heme
KW  - Molecular Dynamics Simulation
KW  - Phylogeny
KW  - Protein Structure, Secondary
KW  - Sequence Homology, Amino Acid
TI  - Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
TY  - research article
VL  - 12
ER  -