RT Journal Article
T1 The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial
A1 Blanco-Rojo, Ruth
A1 Alcala-Diaz, Juan F.
A1 Wopereis, Suzan
A1 Perez-Martinez, Pablo
A1 Quintana-Navarro, Gracia M.
A1 Marin, Carmen
A1 Ordovas, Jose M.
A1 van Ommen, Ben
A1 Perez-Jimenez, Francisco
A1 Delgado-Lista, Javier
A1 Lopez-Miranda, Jose
K1 Beta cell function
K1 Dietary intervention
K1 Insulin resistance
K1 Low-fat diet
K1 Mediterranean diet
K1 Mediterranean diet
K1 Glucose-tolerance
K1 Skeletal-muscle
K1 Life-style
K1 Prevention
K1 Sensitivity
K1 Health
K1 Risk
K1 Metabolism
K1 Secretion
AB Aims/hypothesis The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function.Methods The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREVDIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (<28% fat). At baseline, the patients were classified into four phenotypes according to the type of IR: (1) no IR; (2) muscle IR; (3) liver IR; (4) muscle+liver IR. The hepatic insulin resistance index (HIRI), muscular insulin sensitivity index (MISI) and disposition index were analysed at baseline and after 2 years of follow-up. Results At baseline, 322 patients presented no IR, 106 presented muscle IR, 109 presented liver IR, and 105 presented muscle+liver IR. With both dietary interventions, HIRI decreased in all patients (p<0.001) and MISI increased in muscle IR and muscle+liver IR patients (p<0.01). Long-term intake of the Mediterranean diet increased the disposition index and insulinogenic index in the muscle IR patients (p=0.042 and p=0.044, respectively) and the disposition index in the muscle+liver IR patients (p=0.048), whereas the low-fat diet increased the disposition index in the liver IR patients (p=0.017).Conclusions/interpretation Although both diets improve insulin sensitivity, there are differences based on basal IR phenotypes. Moreover, according to insulinogenic and disposition index data, a low-fat diet might be more beneficial topatients with liver IR, whereas patients with muscle IR and muscle+liver IR might benefit more from a Mediterranean diet.
PB Springer
SN 0012-186X
YR 2015
FD 2015-09-08
LK http://hdl.handle.net/10668/18621
UL http://hdl.handle.net/10668/18621
LA en
NO Blanco-Rojo R, Alcala-Diaz JF, Wopereis S, Perez-Martinez P, Quintana-Navarro GM, Marin C, et al. The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial. Diabetologia. 2016 Jan;59(1):67-76
DS RISalud
RD Apr 8, 2025