TY - JOUR AU - Quijada-Álamo, Miguel AU - Hernández-Sánchez, María AU - Robledo, Cristina AU - Hernández-Sánchez, Jesús-María AU - Benito, Rocío AU - Montaño, Adrián AU - Rodríguez-Vicente, Ana E AU - Quwaider, Dalia AU - Martín, Ana-África AU - García-Álvarez, María AU - Vidal-Manceñido, María Jesús AU - Ferrer-Garrido, Gonzalo AU - Delgado-Beltrán, María-Pilar AU - Galende, Josefina AU - Rodríguez, Juan-Nicolás AU - Martín-Núñez, Guillermo AU - Alonso, José-María AU - García de Coca, Alfonso AU - Queizán, José A AU - Sierra, Magdalena AU - Aguilar, Carlos AU - Kohlmann, Alexander AU - Hernández, José-Ángel AU - González, Marcos AU - Hernández-Rivas, Jesús-María PY - 2017 DO - 10.1186/s13045-017-0450-y UR - http://hdl.handle.net/10668/11085 T2 - Journal of hematology & oncology AB - Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease. Although CLL has been traditionally considered as a mature B cell leukemia, few independent studies have shown that the genetic alterations may appear in CD34+... LA - en KW - Chromosomal abnormality KW - Chronic lymphocytic leukemia KW - FISH KW - Hematopoietic progenitors KW - Mutation KW - Next-generation sequencing KW - Antigens, CD19 KW - Antigens, CD34 KW - Chromosome Aberrations KW - Hematopoietic Stem Cells KW - High-Throughput Nucleotide Sequencing KW - Humans KW - In Situ Hybridization, Fluorescence KW - Leukemia, Lymphocytic, Chronic, B-Cell KW - Mutation TI - Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia. TY - research article VL - 10 ER -