RT Journal Article
T1 Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
A1 Zamora-Ros, Raul
A1 Cayssials, Valerie
A1 Franceschi, Silvia
A1 Kyrø, Cecilie
A1 Weiderpass, Elisabete
A1 Hennings, Joakim
A1 Sandström, Maria
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Truong, Therese
A1 Mancini, Francesca Romana
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Martimianaki, Georgia
A1 Palli, Domenico
A1 Krogh, Vittorio
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Lasheras, Cristina
A1 Rodríguez-Barranco, Miguel
A1 Amiano, Pilar
A1 Colorado-Yohar, Sandra M
A1 Ardanaz, Eva
A1 Almquist, Martin
A1 Ericson, Ulrika
A1 Bueno-de-Mesquita, H Bas
A1 Vermeulen, Roel
A1 Schmidt, Julie A
A1 Byrnes, Graham
A1 Scalbert, Augustin
A1 Agudo, Antonio
A1 Rinaldi, Sabina
K1 EPIC
K1 cohort
K1 flavonoids
K1 intake
K1 polyphenols
K1 thyroid cancer
AB Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.
PB John Wiley & Sons, Inc.
YR 2019
FD 2019-06-18
LK http://hdl.handle.net/10668/14303
UL http://hdl.handle.net/10668/14303
LA en
NO Zamora-Ros R, Cayssials V, Franceschi S, Kyrø C, Weiderpass E, Hennings J, et al. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer. 2020 Apr 1;146(7):1841-1850.
NO The authors thank Bertrand Hémon for his valuable help with the European Prospective Investigation into Cancer and Nutrition (EPIC) database. This study was supported by the Institute of Health Carlos III, Spain (CP15/00100), and cofounded by the European Regional Development Fund (ERDF) “A way to build Europe.” The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); European Research Council (ERC-2009-AdG 232997); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, AGAUR - Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds RD12/0036/0018, cofounded by European Regional Development Fund (ERDF) “A way to build Europe (Spain)”; Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). We thank CERCA Programme/Generalitat de Catalunya for institutional support. R.Z.-R. was supported by the “Miguel Servet” program (CP15/00100) from the Institute of Health Carlos III and European Social Fund (ESF).
DS RISalud
RD Apr 6, 2025