RT Journal Article
T1 A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
A1 Ramdas, Shweta
A1 Judd, Jonathan
A1 Graham, Sarah E
A1 Kanoni, Stavroula
A1 Wang, Yuxuan
A1 Surakka, Ida
A1 Wenz, Brandon
A1 Clarke, Shoa L
A1 Chesi, Alessandra
A1 Wells, Andrew
A1 Bhatti, Konain Fatima
A1 Vedantam, Sailaja
A1 Winkler, Thomas W
A1 Locke, Adam E
A1 Marouli, Eirini
A1 Zajac, Greg J M
A1 Wu, Kuan-Han H
A1 Ntalla, Ioanna
A1 Hui, Qin
A1 Klarin, Derek
A1 Hilliard, Austin T
A1 Wang, Zeyuan
A1 Xue, Chao
A1 Thorleifsson, Gudmar
A1 Helgadottir, Anna
A1 Gudbjartsson, Daniel F
A1 Holm, Hilma
A1 Olafsson, Isleifur
A1 Hwang, Mi Yeong
A1 Han, Sohee
A1 Akiyama, Masato
A1 Sakaue, Saori
A1 Terao, Chikashi
A1 Kanai, Masahiro
A1 Zhou, Wei
A1 Brumpton, Ben M
A1 Rasheed, Humaira
A1 Havulinna, Aki S
A1 Veturi, Yogasudha
A1 Pacheco, Jennifer Allen
A1 Rosenthal, Elisabeth A
A1 Lingren, Todd
A1 Feng, QiPing
A1 Kullo, Iftikhar J
A1 Narita, Akira
A1 Takayama, Jun
A1 Martin, Hilary C
A1 Hunt, Karen A
A1 Trivedi, Bhavi
A1 Haessler, Jeffrey
A1 Giulianini, Franco
A1 Bradford, Yuki
A1 Miller, Jason E
A1 Campbell, Archie
A1 Lin, Kuang
A1 Millwood, Iona Y
A1 Rasheed, Asif
A1 Hindy, George
A1 Faul, Jessica D
A1 Zhao, Wei
A1 Weir, David R
A1 Turman, Constance
A1 Huang, Hongyan
A1 Graff, Mariaelisa
A1 Choudhury, Ananyo
A1 Sengupta, Dhriti
A1 Mahajan, Anubha
A1 Brown, Michael R
A1 Zhang, Weihua
A1 Yu, Ketian
A1 Schmidt, Ellen M
A1 Pandit, Anita
A1 Gustafsson, Stefan
A1 Yin, Xianyong
A1 Luan, Jian'an
A1 Zhao, Jing-Hua
A1 Matsuda, Fumihiko
A1 Jang, Hye-Mi
A1 Yoon, Kyungheon
A1 Medina-Gomez, Carolina
A1 Pitsillides, Achilleas
A1 Hottenga, Jouke Jan
A1 Wood, Andrew R
A1 Ji, Yingji
A1 Gao, Zishan
A1 Haworth, Simon
A1 Mitchell, Ruth E
A1 Chai, Jin Fang
A1 Aadahl, Mette
A1 Bjerregaard, Anne A
A1 Yao, Jie
A1 Manichaikul, Ani
A1 Lee, Wen-Jane
A1 Hsiung, Chao Agnes
A1 Warren, Helen R
A1 Ramirez, Julia
A1 Bork-Jensen, Jette
A1 Kårhus, Line L
A1 Goel, Anuj
A1 Sabater-Lleal, Maria
A1 Noordam, Raymond
A1 Mauro, Pala
A1 Matteo, Floris
A1 McDaid, Aaron F
A1 Marques-Vidal, Pedro
A1 Wielscher, Matthias
A1 Trompet, Stella
A1 Sattar, Naveed
A1 Møllehave, Line T
A1 Munz, Matthias
A1 Zeng, Lingyao
A1 Huang, Jianfeng
A1 Yang, Bin
A1 Poveda, Alaitz
A1 Kurbasic, Azra
A1 Schönherr, Sebastian
A1 Forer, Lukas
A1 Scholz, Markus
A1 Galesloot, Tessel E
A1 Bradfield, Jonathan P
A1 Ruotsalainen, Sanni E
A1 Daw, E Warwick
A1 Zmuda, Joseph M
A1 Mitchell, Jonathan S
A1 Fuchsberger, Christian
A1 Christensen, Henry
A1 Brody, Jennifer A
A1 Le, Phuong
A1 Feitosa, Mary F
A1 Wojczynski, Mary K
A1 Hemerich, Daiane
A1 Preuss, Michael
A1 Mangino, Massimo
A1 Christofidou, Paraskevi
A1 Verweij, Niek
A1 Benjamins, Jan W
A1 Engmann, Jorgen
A1 Noah, Tsao L
A1 Verma, Anurag
A1 Slieker, Roderick C
A1 Lo, Ken Sin
A1 Zilhao, Nuno R
A1 Kleber, Marcus E
A1 Delgado, Graciela E
A1 Huo, Shaofeng
A1 Ikeda, Daisuke D
A1 Iha, Hiroyuki
A1 Yang, Jian
A1 Liu, Jun
A1 Demirkan, Ayşe
A1 Leonard, Hampton L
A1 Marten, Jonathan
A1 Emmel, Carina
A1 Schmidt, Börge
A1 Smyth, Laura J
A1 Cañadas-Garre, Marisa
A1 Wang, Chaolong
A1 Nakatochi, Masahiro
A1 Wong, Andrew
A1 Hutri-Kähönen, Nina
A1 Sim, Xueling
A1 Xia, Rui
A1 Huerta-Chagoya, Alicia
A1 Fernandez-Lopez, Juan Carlos
A1 Lyssenko, Valeriya
A1 Nongmaithem, Suraj S
A1 Sankareswaran, Alagu
A1 Irvin, Marguerite R
A1 Oldmeadow, Christopher
A1 Kim, Han-Na
A1 Ryu, Seungho
A1 Timmers, Paul R H J
A1 Arbeeva, Liubov
A1 Dorajoo, Rajkumar
A1 Lange, Leslie A
A1 Prasad, Gauri
A1 Lorés-Motta, Laura
A1 Pauper, Marc
A1 Long, Jirong
A1 Li, Xiaohui
A1 Theusch, Elizabeth
A1 Takeuchi, Fumihiko
A1 Spracklen, Cassandra N
A1 Loukola, Anu
A1 Bollepalli, Sailalitha
A1 Warner, Sophie C
A1 Wang, Ya Xing
A1 Wei, Wen B
A1 Nutile, Teresa
A1 Ruggiero, Daniela
A1 Sung, Yun Ju
A1 Chen, Shufeng
A1 Liu, Fangchao
A1 Yang, Jingyun
A1 Kentistou, Katherine A
A1 Banas, Bernhard
A1 Morgan, Anna
A1 Meidtner, Karina
A1 Bielak, Lawrence F
A1 Smith, Jennifer A
A1 Hebbar, Prashantha
A1 Farmaki, Aliki-Eleni
A1 Hofer, Edith
A1 Lin, Maoxuan
A1 Concas, Maria Pina
A1 Vaccargiu, Simona
A1 van der Most, Peter J
A1 Pitkänen, Niina
A1 Cade, Brian E
A1 van der Laan, Sander W
A1 Chitrala, Kumaraswamy Naidu
A1 Weiss, Stefan
A1 Bentley, Amy R
A1 Doumatey, Ayo P
A1 Adeyemo, Adebowale A
A1 Lee, Jong Young
A1 Petersen, Eva R B
A1 Nielsen, Aneta A
A1 Choi, Hyeok Sun
A1 Nethander, Maria
A1 Freitag-Wolf, Sandra
A1 Southam, Lorraine
A1 Rayner, Nigel W
A1 Wang, Carol A
A1 Lin, Shih-Yi
A1 Wang, Jun-Sing
A1 Couture, Christian
A1 Lyytikäinen, Leo-Pekka
A1 Nikus, Kjell
A1 Cuellar-Partida, Gabriel
A1 Vestergaard, Henrik
A1 Hidalgo, Bertha
A1 Giannakopoulou, Olga
A1 Cai, Qiuyin
A1 Obura, Morgan O
A1 van Setten, Jessica
A1 He, Karen Y
A1 Tang, Hua
A1 Terzikhan, Natalie
A1 Shin, Jae Hun
A1 Jackson, Rebecca D
A1 Reiner, Alexander P
A1 Martin, Lisa Warsinger
A1 Chen, Zhengming
A1 Li, Liming
A1 Kawaguchi, Takahisa
A1 Thiery, Joachim
A1 Bis, Joshua C
A1 Launer, Lenore J
A1 Li, Huaixing
A1 Nalls, Mike A
A1 Raitakari, Olli T
A1 Ichihara, Sahoko
A1 Wild, Sarah H
A1 Nelson, Christopher P
A1 Campbell, Harry
A1 Jäger, Susanne
A1 Nabika, Toru
A1 Al-Mulla, Fahd
A1 Niinikoski, Harri
A1 Braund, Peter S
A1 Kolcic, Ivana
A1 Kovacs, Peter
A1 Giardoglou, Tota
A1 Katsuya, Tomohiro
A1 de Kleijn, Dominique
A1 de Borst, Gert J
A1 Kim, Eung Kweon
A1 Adams, Hieab H H
A1 Ikram, M Arfan
A1 Zhu, Xiaofeng
A1 Asselbergs, Folkert W
A1 Kraaijeveld, Adriaan O
A1 Beulens, Joline W J
A1 Shu, Xiao-Ou
A1 Rallidis, Loukianos S
A1 Pedersen, Oluf
A1 Hansen, Torben
A1 Mitchell, Paul
A1 Hewitt, Alex W
A1 Kähönen, Mika
A1 Pérusse, Louis
A1 Bouchard, Claude
A1 Tönjes, Anke
A1 Ida Chen, Yii-Der
A1 Pennell, Craig E
A1 Mori, Trevor A
A1 Lieb, Wolfgang
A1 Franke, Andre
A1 Ohlsson, Claes
A1 Mellström, Dan
A1 Cho, Yoon Shin
A1 Lee, Hyejin
A1 Yuan, Jian-Min
A1 Koh, Woon-Puay
A1 Rhee, Sang Youl
A1 Woo, Jeong-Taek
A1 Heid, Iris M
A1 Stark, Klaus J
A1 Zimmermann, Martina E
A1 Völzke, Henry
A1 Homuth, Georg
A1 Evans, Michele K
A1 Zonderman, Alan B
A1 Polasek, Ozren
A1 Pasterkamp, Gerard
A1 Hoefer, Imo E
A1 Redline, Susan
A1 Pahkala, Katja
A1 Oldehinkel, Albertine J
A1 Snieder, Harold
A1 Biino, Ginevra
A1 Schmidt, Reinhold
A1 Schmidt, Helena
A1 Bandinelli, Stefania
A1 Dedoussis, George
A1 Thanaraj, Thangavel Alphonse
A1 Peyser, Patricia A
A1 Kato, Norihiro
A1 Schulze, Matthias B
A1 Girotto, Giorgia
A1 Böger, Carsten A
A1 Jung, Bettina
A1 Joshi, Peter K
A1 Bennett, David A
A1 De Jager, Philip L
A1 Lu, Xiangfeng
A1 Mamakou, Vasiliki
A1 Brown, Morris
A1 Caulfield, Mark J
A1 Munroe, Patricia B
A1 Guo, Xiuqing
A1 Ciullo, Marina
A1 Jonas, Jost B
A1 Samani, Nilesh J
A1 Kaprio, Jaakko
A1 Pajukanta, Päivi
A1 Tusié-Luna, Teresa
A1 Aguilar-Salinas, Carlos A
A1 Adair, Linda S
A1 Bechayda, Sonny Augustin
A1 de Silva, H Janaka
A1 Wickremasinghe, Ananda R
A1 Krauss, Ronald M
A1 Wu, Jer-Yuarn
A1 Zheng, Wei
A1 den Hollander, Anneke I
A1 Bharadwaj, Dwaipayan
A1 Correa, Adolfo
A1 Wilson, James G
A1 Lind, Lars
A1 Heng, Chew-Kiat
A1 Nelson, Amanda E
A1 Golightly, Yvonne M
A1 Wilson, James F
A1 Penninx, Brenda
A1 Kim, Hyung-Lae
A1 Attia, John
A1 Scott, Rodney J
A1 Rao, D C
A1 Arnett, Donna K
A1 Walker, Mark
A1 Scott, Laura J
A1 Koistinen, Heikki A
A1 Chandak, Giriraj R
A1 Mercader, Josep M
A1 Villalpando, Clicerio Gonzalez
A1 Orozco, Lorena
A1 Fornage, Myriam
A1 Tai, E Shyong
A1 van Dam, Rob M
A1 Lehtimäki, Terho
A1 Chaturvedi, Nish
A1 Yokota, Mitsuhiro
A1 Liu, Jianjun
A1 Reilly, Dermot F
A1 McKnight, Amy Jayne
A1 Kee, Frank
A1 Jöckel, Karl-Heinz
A1 McCarthy, Mark I
A1 Palmer, Colin N A
A1 Vitart, Veronique
A1 Hayward, Caroline
A1 Simonsick, Eleanor
A1 van Duijn, Cornelia M
A1 Jin, Zi-Bing
A1 Lu, Fan
A1 Hishigaki, Haretsugu
A1 Lin, Xu
A1 März, Winfried
A1 Gudnason, Vilmundur
A1 Tardif, Jean-Claude
A1 Lettre, Guillaume
A1 T Hart, Leen M
A1 Elders, Petra J M
A1 Rader, Daniel J
A1 Damrauer, Scott M
A1 Kumari, Meena
A1 Kivimaki, Mika
A1 van der Harst, Pim
A1 Spector, Tim D
A1 Loos, Ruth J F
A1 Province, Michael A
A1 Parra, Esteban J
A1 Cruz, Miguel
A1 Psaty, Bruce M
A1 Brandslund, Ivan
A1 Pramstaller, Peter P
A1 Rotimi, Charles N
A1 Christensen, Kaare
A1 Ripatti, Samuli
A1 Widén, Elisabeth
A1 Hakonarson, Hakon
A1 Grant, Struan F A
A1 Kiemeney, Lambertus
A1 de Graaf, Jacqueline
A1 Loeffler, Markus
A1 Kronenberg, Florian
A1 Gu, Dongfeng
A1 Erdmann, Jeanette
A1 Schunkert, Heribert
A1 Franks, Paul W
A1 Linneberg, Allan
A1 Jukema, J Wouter
A1 Khera, Amit V
A1 Männikkö, Minna
A1 Jarvelin, Marjo-Riitta
A1 Kutalik, Zoltan
A1 Francesco, Cucca
A1 Mook-Kanamori, Dennis O
A1 Willems van Dijk, Ko
A1 Watkins, Hugh
A1 Strachan, David P
A1 Grarup, Niels
A1 Sever, Peter
A1 Poulter, Neil
A1 Huey-Herng Sheu, Wayne
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A1 Timpson, Nicholas J
A1 Cheng, Ching-Yu
A1 Wong, Tien-Yin
A1 Khor, Chiea Chuen
A1 Li, Hengtong
A1 Sabanayagam, Charumathi
A1 Peters, Annette
A1 Gieger, Christian
A1 Hattersley, Andrew T
A1 Pedersen, Nancy L
A1 Magnusson, Patrik K E
A1 Boomsma, Dorret I
A1 de Geus, Eco J C
A1 Cupples, L Adrienne
A1 van Meurs, Joyce B J
A1 Ikram, Arfan
A1 Ghanbari, Mohsen
A1 Gordon-Larsen, Penny
A1 Huang, Wei
A1 Kim, Young Jin
A1 Tabara, Yasuharu
A1 Wareham, Nicholas J
A1 Langenberg, Claudia
A1 Zeggini, Eleftheria
A1 Tuomilehto, Jaakko
A1 Kuusisto, Johanna
A1 Laakso, Markku
A1 Ingelsson, Erik
A1 Abecasis, Goncalo
A1 Chambers, John C
A1 Kooner, Jaspal S
A1 de Vries, Paul S
A1 Morrison, Alanna C
A1 Hazelhurst, Scott
A1 Ramsay, Michèle
A1 North, Kari E
A1 Daviglus, Martha
A1 Kraft, Peter
A1 Martin, Nicholas G
A1 Whitfield, John B
A1 Abbas, Shahid
A1 Saleheen, Danish
A1 Walters, Robin G
A1 Holmes, Michael V
A1 Black, Corri
A1 Smith, Blair H
A1 Baras, Aris
A1 Justice, Anne E
A1 Buring, Julie E
A1 Ridker, Paul M
A1 Chasman, Daniel I
A1 Kooperberg, Charles
A1 Tamiya, Gen
A1 Yamamoto, Masayuki
A1 van Heel, David A
A1 Trembath, Richard C
A1 Wei, Wei-Qi
A1 Jarvik, Gail P
A1 Namjou, Bahram
A1 Hayes, M Geoffrey
A1 Ritchie, Marylyn D
A1 Jousilahti, Pekka
A1 Salomaa, Veikko
A1 Hveem, Kristian
A1 Åsvold, Bjørn Olav
A1 Kubo, Michiaki
A1 Kamatani, Yoichiro
A1 Okada, Yukinori
A1 Murakami, Yoshinori
A1 Kim, Bong-Jo
A1 Thorsteinsdottir, Unnur
A1 Stefansson, Kari
A1 Zhang, Jifeng
A1 Chen, Y Eugene
A1 Ho, Yuk-Lam
A1 Lynch, Julie A
A1 Tsao, Philip S
A1 Chang, Kyong-Mi
A1 Cho, Kelly
A1 O'Donnell, Christopher J
A1 Gaziano, John M
A1 Wilson, Peter
A1 Mohlke, Karen L
A1 Frayling, Timothy M
A1 Hirschhorn, Joel N
A1 Kathiresan, Sekar
A1 Boehnke, Michael
A1 Million Veterans Program, 
A1 Global Lipids Genetics Consortium, 
A1 Struan Grant, 
A1 Natarajan, Pradeep
A1 Sun, Yan V
A1 Morris, Andrew P
A1 Deloukas, Panos
A1 Peloso, Gina
A1 Assimes, Themistocles L
A1 Willer, Cristen J
A1 Zhu, Xiang
A1 Brown, Christopher D
K1 complex traits
K1 fine-mapping
K1 functional genomics
K1 lipid biology
K1 post-GWAS
K1 regulatory mechanism
K1 variant prioritization
AB A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
PB Cell Press
YR 2022
FD 2022/01/23
LK http://hdl.handle.net/10668/21878
UL http://hdl.handle.net/10668/21878
LA en
NO Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I,, et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet. 2022 Aug 4;109(8):1366-1387.
DS RISalud
RD Apr 8, 2025