RT Journal Article
T1 Magnetofection as a new tool to study microglia biology.
A1 Venero, Jose Luis
A1 Burguillos, Miguel Angel
K1 Microglia
K1 Brain
K1 Neurons
K1 Synapses
AB Microglia are the resident macrophages of the brain, originally described by Pío del Río-Hortega (a student of Santiago Ramon y Cajal) in a series of studies in 1919. Since those pioneering studies, many others have followed to describe microglia as complex and multitasking cells with many diverse roles under physiological (e.g. their key role in synapse pruning during development) or diseased conditions. Microglia exist as sentinels or surveyors of the environment that surround neurons, becoming reactive upon a wide array of stimuli and consequently developing an appropriate inflammatory response. In fact, a neuroinflammatory response driven by microglia is found in virtually every disease process that occurs within the central nervous system. Therefore, a better understanding of the mechanisms governing the microglia response is the key to improving the outcome of neurodegenerative conditions.
PB Wolters Kluwer - Medknow Publications and Media Pvt. Ltd.
SN 1673-5374
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13469
UL http://hdl.handle.net/10668/13469
LA en
NO Venero JL, Burguillos MA. Magnetofection as a new tool to study microglia biology. Neural Regen Res. 2019 May;14(5):767-768.
DS RISalud
RD Apr 17, 2025