TY  - JOUR
AU  - Herrera-Martinez, Aura D
AU  - Feelders, Richard A
AU  - Van den Dungen, Rosanna
AU  - Dogan-Oruc, Fadime
AU  - van Koetsveld, Peter M
AU  - Castaño, Justo P
AU  - de Herder, Wouter W
AU  - Hofland, Leo J
PY  - 2019
DO  - 10.1159/000502200
UR  - http://hdl.handle.net/10668/14256
T2  - Neuroendocrinology
AB  - Serotonin, a biologically active amine, is related to carcinoid syndrome in functioning neuroendocrine tumors (NETs). Telotristat ethyl is a novel inhibitor of the tryptophan hydroxylase (TPH), a key enzyme in the production of serotonin. While its...
LA  - en
KW  - Growth
KW  - In vitro effect
KW  - Neuroendocrine tumors
KW  - Serotonin secretion
KW  - Telotristat
KW  - Dose-response relationship, drug
KW  - Enzyme inhibitors
KW  - Humans
KW  - In vitro techniques
KW  - Neuroendocrine tumors
KW  - Pancreatic neoplasms
KW  - Phenylalanine
KW  - Pyrimidines
KW  - Serotonin
KW  - Tryptophan hydroxylase
KW  - Tumor cells, cultured
TI  - Effect of the Tryptophan Hydroxylase Inhibitor Telotristat on Growth and Serotonin Secretion in 2D and 3D Cultured Pancreatic Neuroendocrine Tumor Cells.
TY  - Research article
VL  - 110
ER  -