TY - JOUR AU - de Celis-Ruiz, Elena AU - Fuentes, Blanca AU - Moniche, Francisco AU - Montaner, Joan AU - Borobia, Alberto M. AU - Gutiérrez-Fernández, Maria AU - Díez-Tejedor, Exuperio PY - 2021 DO - 10.1136/bmjopen-2021-051790 UR - http://hdl.handle.net/10668/3800 T2 - BMJ Open AB - Introduction: Stroke is a serious public health problem, given it is a major cause of disability worldwide despite the spread of recanalisation therapies. Enhancement of brain plasticity with stem cell administration is a promising innovative therapy... LA - en PB - B M J KW - Brain KW - Clinical trial protocol KW - Mesenchymal stem cells KW - Ischemic stroke KW - Encéfalo KW - Protocolo de ensayo clínico KW - Células madre mesenquimatosas KW - Accidente cerebrovascular isquémico KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Method KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as... KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome KW - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation KW - Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Cerebrovascular Disorders::Stroke KW - Medical Subject Headings::Anatomy::Cells::Stem Cells TI - Allogeneic adipose tissue-derived mesenchymal stem cells in ischaemic stroke (AMASCIS-02): a phase IIb, multicentre, double-blind, placebo-controlled clinical trial protocol TY - research article ER -