RT Journal Article
T1 Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination.
A1 Herrero-Fernández, Inés
A1 Rosado-Sánchez, Isaac
A1 Genebat, Miguel
A1 Tarancón-Díez, Laura
A1 Rodríguez-Méndez, María Mar
A1 Pozo-Balado, María Mar
A1 Lozano, Carmen
A1 Ruiz-Mateos, Ezequiel
A1 Leal, Manuel
A1 Pacheco, Yolanda M
K1 Activation
K1 CD4 T-cell
K1 Dendritic cells (DC)
K1 HBV vaccine
K1 Inflammation
K1 Ki67
K1 Maraviroc (MVC)
K1 Recent thymic emigrants (RTE)
K1 Treg
K1 hsCRP
AB Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that could account for this effect. We analysed baseline samples of vaccinated subjects under 50 years old (n = 41). We characterized the maturational subsets and the expression of activation, senescence and prone-to-apoptosis markers on CD4 T-cells; we also quantified T-regulatory cells (Treg) and dendritic cell (DC) subsets. We used binary logistic regression to evaluate the immunological impact of MVC-cART, correlation with MVC exposure and linear regression for association with the magnitude of the HBV vaccine response. HIV-infected subjects on MVC-cART prior to vaccination showed increased recent thymic emigrants levels and reduced myeloid-DC levels. A longer exposure to MVC-cART was associated with lower frequencies of Tregs and activated and proliferating CD4 T-cells. Furthermore, the frequencies of activated and proliferating CD4 T-cells were inversely associated with the magnitude of the HBV vaccine response. The beneficial effect of MVC-cART in the HBV vaccine response in subjects below 50 years old could be partially mediated by its reducing effect on the frequencies of activated and proliferating CD4 T-cells prior to vaccination.
YR 2018
FD 2018-08-29
LK http://hdl.handle.net/10668/12881
UL http://hdl.handle.net/10668/12881
LA en
DS RISalud
RD Apr 9, 2025