TY - GEN AU - Kopecka, Joanna AU - Salaroglio, Iris C. AU - Perez-Ruiz, Elizabeth AU - Sarmento-Ribeiro, Ana Bela AU - Saponara, Simona AU - De Las Rivas, Javier AU - Riganti, Chiara PY - 2021 DO - 10.1016/j.drup.2021.100787 SN - 1368-7646 UR - https://hdl.handle.net/10668/26999 T2 - Drug resistance updates AB - Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive malignant clones displaying resistance to radiotherapy, conventional chemotherapy or targeted therapy. The recent introduction of immunotherapy, based on immune... LA - en PB - Churchill livingstone KW - Drug resistance KW - Immune checkpoint inhibitors KW - CAR T-cells KW - Tumor hypoxia KW - Renal-cell carcinoma KW - Lenvatinib plus pembrolizumab KW - Advanced hepatocellular-carcinoma KW - Self-assembling nanoparticles KW - High-level resistance KW - Cd8(+) t-cells KW - Multidrug-resistance KW - Cancer-cells KW - Pd-l1 expression KW - Inducible-factor TI - Hypoxia as a driver of resistance to immunotherapy TY - review VL - 59 ER -