RT Journal Article
T1 Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability
A1 Duran-Aniotz, Claudia
A1 Moreno-Gonzalez, Ines
A1 Gamez, Nazaret
A1 Perez-Urrutia, Nelson
A1 Vegas-Gomez, Laura
A1 Soto, Claudio
A1 Morales, Rodrigo
K1 Alzheimer’s disease
K1 Amyloid-beta
K1 Pathology
K1 Prions
K1 Strains
K1 Enfermedad de alzheimer
K1 beta-Amiloides
K1 Patología
K1 Priones
AB Amyloid-β (Aβ) misfolding is one of the hallmark pathological features of Alzheimer's disease (AD). AD can manifest with diverse symptomatology including variable rates of cognitive decline, duration of clinical disease, and other detrimental changes. Several reports suggest that conformational diversity in misfolded Aβ is a leading factor for clinical variability in AD, analogous to what it has been described for prion strains in prion diseases. Notably, prion strains generate diverse patterns of misfolded protein deposition in the brains of affected individuals. Here, we tested the in vivo prion-like transmission features of four AD brains displaying particular patterns of amyloidosis. AD brains induced different phenotypes in recipient mice, as evaluated by their specific seeding activity, as well as the total amount of Aβ deposited surrounding vascular structures and the reactivity of amyloid pathology to thioflavin S. Our results support the notion that AD-subtypes are encoded in disease-associated Aβ. Further research exploring whether AD include a spectrum of different clinical conditions or syndromes may pave the way to personalized diagnosis and treatments.
PB BioMed Central, Springer Nature
YR 2021
FD 2021-03-30
LK http://hdl.handle.net/10668/3905
UL http://hdl.handle.net/10668/3905
LA en
NO Duran-Aniotz C, Moreno-Gonzalez I, Gamez N, Perez-Urrutia N, Vegas-Gomez L, Soto C, et al. Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability. Acta Neuropathol Commun. 2021 Mar 30;9(1):56
DS RISalud
RD Apr 8, 2025