RT Journal Article
T1 Impact of species hybridization on the clinical management of schistosomiasis: A prospective study
A1 Salas-Coronas, Joaquín
A1 Bargues, M Dolores
A1 Fernandez-Soto, Pedro
A1 Soriano-Perez, Manuel Jesus
A1 Artigas, Patricio
A1 Vazquez-Villegas, Jose
A1 Villarejo-Ordoñez, Antonio
A1 Sanchez-Sanchez, Jose Carlos
A1 Cabeza-Barrera, Maria Isabel
A1 Febrer-Sendra, Begoña
A1 De Elias-Escribano, Alejandra
A1 Crego-Vicente, Beatriz
A1 Fantozzi, Maria C
A1 Garcia-Bernalt Diego, juan
A1 Castillo-Fenandez, Nerea
A1 Borrego-Jimenez, Jaime
A1 Muro, Antonio
A1 Luzon-Garcia, Maria Pilar
K1 Hybrids
K1 Migrants
K1 Schistosoma
K1 Schistosomiasis
K1 Ultrasound
AB Background: Species hybridization represents a real concern in terms of parasite transmission, epidemiology and morbidity of schistosomiasis. It is greatly important to better understand the impact of species hybridization for the clinical management.Methods: A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including Schistosoma serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of Schistosoma hybrids with carriers of only genetically pure forms.Results: A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of Schistosoma hybrids. As compared with patients infected with S. haematobium alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % vs 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.Conclusions: The presence of Schistosoma hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.
PB Elsevier Science
SN 1477-8939
YR 2024
FD 2024-07-23
LK https://hdl.handle.net/10668/24308
UL https://hdl.handle.net/10668/24308
LA en
NO Salas-Coronas J, Bargues MD, Fernández-Soto P, Soriano-Pérez MJ, Artigas P, Vázquez-Villegas J, et al. Impact of species hybridization on the clinical management of schistosomiasis: A prospective study. Travel Med Infect Dis. 2024;61:102744.
NO This study was supported by Proyecto de Investigación en Salud PI-0001-2019, Consejería de Salud y Familias de la Junta de Andalucía, Sevilla, co-financed with FEDER funds (European Regional Development Fund, “A way to make Europe”/“Investing in your future”) (J.S·C.); the Research group PAIDI CTS582 of the Regional Ministry of Gender, Health, and Social Policy of the Government of Andalusia (J.S·C); Ayudas para Grupos de Investigación de Excelencia (PROMETEO) (grant number 2021/004), Generalitat Valenciana, Valencia (M.D.B.); and conducted within the activities developed by the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) (grant number CB21/13/00056), Instituto de Salud Carlos III, Ministry of Science and Innovation and European Union—NextGenerationEU (M.D.B.). This study was also funded by the Instituto de Salud Carlos III (ISCIII) through the project PI22/01721 and co-funded by the European Union (P·F-S.). We also acknowledge support by the Predoctoral Fellowship Program of the University of Salamanca and co-financing by Santander Bank (J.G-B.D.) and by the Predoctoral Fellowship Program of Junta de Castilla y León co-funded by Fondo Social Europeo (BDNS (Identif.): 422,058, B·F-S. and BDNS (Identif.): 487,971, B.C-V.).
DS RISalud
RD Apr 10, 2025