RT Journal Article
T1 Design of an antigenic determinant of cefaclor: Chemical structure-IgE recognition relationship.
A1 Martin-Serrano, Angela
A1 Mayorga, Cristobalina
A1 Barrionuevo, Esther
A1 Perez, Natalia
A1 Romano, Antonino
A1 Moreno, Esther
A1 Ariza, Adriana
A1 Perez-Inestrosa, Ezequiel
A1 Torres, Maria J
A1 Montañez, Maria I
AB Like penicillins, cephalosporins are common antibiotics inducing adverse drug reactions mediated by specific immunologic mechanisms.1 The ‘‘hapten hypothesis’’ states that b-lactams can cause an allergic response only after binding covalently to carrier proteins. In case of cephalosporins, the epitope or antigenic determinant consists of the chemical structure derived after cephalosporin-protein linkage. The lack of knowledge regarding its epitope has hampered the development of standardized in vitro tests to diagnose cephalosporin allergy. Therefore, diagnosis still relies on skin testing and drug provocation tests,2 which, however, are risky, especially for patients with severe reactions. This forces physicians to select alternative b-lactams that, although safe for patients with allergy, may be less effective and show disadvantages related to costs and bacterial resistance.
PB Elsevier
YR 2019
FD 2019-12-17
LK http://hdl.handle.net/10668/14806
UL http://hdl.handle.net/10668/14806
LA en
NO Martín-Serrano A, Mayorga C, Barrionuevo E, Pérez N, Romano A, Moreno E, et al. Design of an antigenic determinant of cefaclor: Chemical structure-IgE recognition relationship. J Allergy Clin Immunol. 2020 Apr;145(4):1301-1304.e4
DS RISalud
RD Apr 12, 2025