RT Journal Article
T1 Oral and oropharyngeal squamous cell carcinoma in young adults: A retrospective study in Granada University Hospital
A1 Cariati, Paolo
A1 Cabello-Serrano, Almudena
A1 Perez-de Perceval-Tara, Miguel
A1 Monsalve-Iglesias, Fernando
A1 Martinez-Lara, Ildefonso
K1 Oral and oropharyngeal squamous cell carcinoma
K1 young adults
K1 poor prognosis
K1 risk factors
K1 Neck-cancer incidence
K1 Risk-factors
K1 Incidence trends
K1 Cavity cancers
K1 Tongue cancer
K1 Head
K1 Age
K1 Mortality
K1 Survival
K1 People
AB Background: This study aims to evaluate and analyze the clinical features and outcomes of oral and oropharyngeal squamous cell carcinoma (SCC) in patients 45 years were randomly selected from the same database. A retrospective analysis was conducted to determine specific features including sites of occurrence, risk factors, sex distribution, socio-economic status, T stage at diagnosis, nodal involvement, degree of tumor differentiation, locoregional failure and overall survival at 5 years was. Further, the results of both groups were compared.Results: The male-female ratio was 1.2:1 in the group of young adults and 2.03:1 in the group of patients with an age of >45 years. No significant differences were found in terms of site, nodal involvement, locoregional failure, and overall survival. However, there were statistically significant differences between the two groups in terms of features such as risk factors, socio-economic status, T stage at diagnosis, and degree of tumor differentiation. The overall 5-year survival rate was 62% for patients >45 years old, whilst for the group of young adults this rate was 48.4% (p=0.17).Conclusions: The poor association between the common risk factors and oral and oropharyngeal cancers in young adults suggests that other pathogenic mechanisms should be investigated. For young patients, the data show evidence of poorer outcomes in terms of overall survival (p=0.17), and locoregional failure (p=0.23). Nevertheless, the literature shows that the results in this field are particularly inconsistent, and further research is therefore needed to provide more in-depth knowledge of the disease in this age group.
PB Medicina oral s l
SN 1698-6946
YR 2017
FD 2017-11-01
LK http://hdl.handle.net/10668/19366
UL http://hdl.handle.net/10668/19366
LA en
DS RISalud
RD Apr 11, 2025