%0 Journal Article
%A Nyssen, Olga P
%A Bordin, Dmitry
%A Tepes, Bojan
%A Pérez-Aisa, Ángeles
%A Vaira, Dino
%A Caldas, Maria
%A Bujanda, Luis
%A Castro-Fernandez, Manuel
%A Lerang, Frode
%A Leja, Marcis
%A Rodrigo, Luís
%A Rokkas, Theodore
%A Kupcinskas, Limas
%A Pérez-Lasala, Jorge
%A Jonaitis, Laimas
%A Shvets, Oleg
%A Gasbarrini, Antonio
%A Simsek, Halis
%A Axon, Anthony T R
%A Buzás, György
%A Machado, Jose Carlos
%A Niv, Yaron
%A Boyanova, Lyudmila
%A Goldis, Adrian
%A Lamy, Vincent
%A Tonkic, Ante
%A Przytulski, Krzysztof
%A Beglinger, Christoph
%A Venerito, Marino
%A Bytzer, Peter
%A Capelle, Lisette
%A Milosavljević, Tomica
%A Milivojevic, Vladimir
%A Veijola, Lea
%A Molina-Infante, Javier
%A Vologzhanina, Liudmila
%A Fadeenko, Galina
%A Ariño, Ines
%A Fiorini, Giulia
%A Garre, Ana
%A Garrido, Jesús
%A F Pérez, Cristina
%A Puig, Ignasi
%A Heluwaert, Frederic
%A Megraud, Francis
%A O'Morain, Colm
%A Gisbert, Javier P
%A Hp-EuReg Investigators
%T European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients.
%D 2020
%U http://hdl.handle.net/10668/16292
%X The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care. International multicentre prospective non-interventional registry starting in 2013 aimed to evaluate the decisions and outcomes in H. pylori management by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events and outcomes. Data monitoring was performed to ensure data quality. Time-trend and geographical analyses were performed. 30 394 patients from 27 European countries were evaluated and 21 533 (78%) first-line empirical H. pylori treatments were included for analysis. Pretreatment resistance rates were 23% to clarithromycin, 32% to metronidazole and 13% to both. Triple therapy with amoxicillin and clarithromycin was most commonly prescribed (39%), achieving 81.5% modified intention-to-treat eradication rate. Over 90% eradication was obtained only with 10-day bismuth quadruple or 14-day concomitant treatments. Longer treatment duration, higher acid inhibition and compliance were associated with higher eradication rates. Time-trend analysis showed a region-dependent shift in prescriptions including abandoning triple therapies, using higher acid-inhibition and longer treatments, which was associated with an overall effectiveness increase (84%-90%). Management of H. pylori infection by European gastroenterologists is heterogeneous, suboptimal and discrepant with current recommendations. Only quadruple therapies lasting at least 10 days are able to achieve over 90% eradication rates. European recommendations are being slowly and heterogeneously incorporated into routine clinical practice, which was associated with a corresponding increase in effectiveness.
%K helicobacter pylori
%K helicobacter pylori - treatment
%~