RT Journal Article
T1 L-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats.
A1 Rodríguez-Gómez, Isabel
A1 Moliz, Juan N
A1 Quesada, Andrés
A1 Montoro-Molina, Sebastian
A1 Vargas-Tendero, Pablo
A1 Osuna, Antonio
A1 Wangensteen, Rosemary
A1 Vargas, Félix
K1 Hyperthyroidism
K1 aorta
K1 heart kidney
K1 hypothyroidism
K1 l-arginine metabolism
K1 rat
AB This study assessed the effects of thyroid hormones on the enzymes involved in l-arginine metabolism and the metabolites generated by the different metabolic pathways. Compounds of l-arginine metabolism were measured in the kidney, heart, aorta, and liver of euthyroid, hyperthyroid, and hypothyroid rats after 6 weeks of treatment. Enzymes studied were NOS isoforms (neuronal [nNOS], inducible [iNOS], and endothelial [eNOS]), arginases I and II, ornithine decarboxylase (ODC), ornithine aminotransferase (OAT), and l-arginine decarboxylase (ADC). Metabolites studied were l-arginine, l-citrulline, spermidine, spermine, and l-proline. Kidney heart and aorta levels of eNOS and iNOS were augmented and reduced (P 
YR 2015
FD 2015-12-15
LK http://hdl.handle.net/10668/9667
UL http://hdl.handle.net/10668/9667
LA en
DS RISalud
RD Apr 5, 2025