%0 Journal Article
%A Rodríguez-Gómez, Isabel
%A Moliz, Juan N
%A Quesada, Andrés
%A Montoro-Molina, Sebastian
%A Vargas-Tendero, Pablo
%A Osuna, Antonio
%A Wangensteen, Rosemary
%A Vargas, Félix
%T L-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats.
%D 2015
%U http://hdl.handle.net/10668/9667
%X This study assessed the effects of thyroid hormones on the enzymes involved in l-arginine metabolism and the metabolites generated by the different metabolic pathways. Compounds of l-arginine metabolism were measured in the kidney, heart, aorta, and liver of euthyroid, hyperthyroid, and hypothyroid rats after 6 weeks of treatment. Enzymes studied were NOS isoforms (neuronal [nNOS], inducible [iNOS], and endothelial [eNOS]), arginases I and II, ornithine decarboxylase (ODC), ornithine aminotransferase (OAT), and l-arginine decarboxylase (ADC). Metabolites studied were l-arginine, l-citrulline, spermidine, spermine, and l-proline. Kidney heart and aorta levels of eNOS and iNOS were augmented and reduced (P 
%K Hyperthyroidism
%K aorta
%K heart kidney
%K hypothyroidism
%K l-arginine metabolism
%K rat
%~